Literature DB >> 3324921

Biochemical modulation of fluorouracil therapy in advanced colorectal cancer.

J Mackintosh1, M H Tattersall.   

Abstract

Fluorouracil has been the mainstay of chemotherapy in colorectal cancer for many years. We report our experience using fluorouracil in combination with other drugs which may modulate the spectrum of activity. Patients have been treated with allopurinol and fluorouracil and with two schedules of methotrexate and fluorouracil. We discuss other possible approaches to modulate fluorouracil action.

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Year:  1987        PMID： 3324921

Source DB:  PubMed          Journal:  Ann Acad Med Singapore        ISSN： 0304-4602            Impact factor:   2.473


  2 in total

1.  Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo.

Authors:  P M McSheehy; M J Prior; J R Griffiths
Journal:  Br J Cancer       Date:  1992-03       Impact factor: 7.640

2.  Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.

Authors:  P M McSheehy; M J Prior; J R Griffiths
Journal:  Br J Cancer       Date:  1989-09       Impact factor: 7.640
  2 in total

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