| Literature DB >> 33248227 |
R Casolino1, C Braconi2, G Malleo3, S Paiella3, C Bassi3, M Milella4, S B Dreyer5, F E M Froeling6, D K Chang5, A V Biankin7, T Golan8.
Abstract
This review summarises the recent evidence on preoperative therapeutic strategies in pancreatic cancer and discusses the rationale for an imminent need for a personalised therapeutic approach in non-metastatic disease. The molecular diversity of pancreatic cancer and its influence on prognosis and treatment response, combined with the failure of 'all-comer' treatments to significantly impact on patient outcomes, requires a paradigm shift towards a genomic-driven approach. This is particularly important in the preoperative, potentially curable setting, where a personalised treatment allocation has the substantial potential to reduce pancreatic cancer mortality.Entities:
Keywords: Pancreatic cancer; neoadjuvant; precision medicine; predictive biomarkers; preoperative; prognostic biomarkers
Mesh:
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Year: 2020 PMID: 33248227 PMCID: PMC7840891 DOI: 10.1016/j.annonc.2020.11.013
Source DB: PubMed Journal: Ann Oncol ISSN: 0923-7534 Impact factor: 32.976