Literature DB >> 33248227

Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine.

R Casolino1, C Braconi2, G Malleo3, S Paiella3, C Bassi3, M Milella4, S B Dreyer5, F E M Froeling6, D K Chang5, A V Biankin7, T Golan8.   

Abstract

This review summarises the recent evidence on preoperative therapeutic strategies in pancreatic cancer and discusses the rationale for an imminent need for a personalised therapeutic approach in non-metastatic disease. The molecular diversity of pancreatic cancer and its influence on prognosis and treatment response, combined with the failure of 'all-comer' treatments to significantly impact on patient outcomes, requires a paradigm shift towards a genomic-driven approach. This is particularly important in the preoperative, potentially curable setting, where a personalised treatment allocation has the substantial potential to reduce pancreatic cancer mortality.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  Pancreatic cancer; neoadjuvant; precision medicine; predictive biomarkers; preoperative; prognostic biomarkers

Mesh:

Substances:

Year:  2020        PMID: 33248227      PMCID: PMC7840891          DOI: 10.1016/j.annonc.2020.11.013

Source DB:  PubMed          Journal:  Ann Oncol        ISSN: 0923-7534            Impact factor:   32.976


  99 in total

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