Luis F Antón-Toro1, Ricardo Bruña2, Isabel Suárez-Méndez3, Ángeles Correas4, Luis M García-Moreno5, Fernando Maestú2. 1. Department of Experimental Psychology, Complutense University of Madrid (UCM), 28223, Madrid, Spain; Laboratory for Cognitive and Computational Neuroscience (UCM - UPM), Center for Biomedical Technology (CBT), 28223, Madrid, Spain. Electronic address: luisfernando.anton@ctb.upm.es. 2. Department of Experimental Psychology, Complutense University of Madrid (UCM), 28223, Madrid, Spain; Laboratory for Cognitive and Computational Neuroscience (UCM - UPM), Center for Biomedical Technology (CBT), 28223, Madrid, Spain; Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain. 3. Department of Experimental Psychology, Complutense University of Madrid (UCM), 28223, Madrid, Spain; Laboratory for Cognitive and Computational Neuroscience (UCM - UPM), Center for Biomedical Technology (CBT), 28223, Madrid, Spain; Department of Structure of Matter, Thermal Physics and Electronics, Complutense University of Madrid (UCM), 28223, Madrid, Spain. 4. Laboratory for Cognitive and Computational Neuroscience (UCM - UPM), Center for Biomedical Technology (CBT), 28223, Madrid, Spain; Department of Psychology, San Diego State University, 5500 Campanile Drive San Diego, CA, 92182-4611, USA. 5. Department of Psychobiology and Methodology in Behavioral Sciences, Complutense University of Madrid (UCM), 28040, Madrid, Spain.
Abstract
BACKGROUND AND AIMS: Adolescent Binge drinking has become an increasing health and social concern, which cause several detrimental consequences for brain integrity. However, research on neurophysiological traits of vulnerability for binge drinking predisposition is limited at this time. In this work, we conducted a two-year longitudinal study with magnetoencephalography (MEG) over a cohort of initially alcohol-naive adolescents with the purpose of characterize inhibitory cortical networks' anomalies prior to alcohol consumption onset in those youths who will transit into binge drinkers years later. METHODS: Sixty-seven participant's inhibitory functional networks, and dysexecutive/impulsivity traits were measured by means of inhibitory task (go/no-go) and questionnaires battery. After a follow-up period of two years, we evaluated their alcohol consumption habits, sub-dividing them in two groups according to their alcohol intake patterns: future binge drinkers (fBD): n = 22; future Light/non-drinkers (fLD): n = 17. We evaluated whole-brain and seed-based functional connectivity profiles, as well as its correlation with impulsive and dysexecutive behaviours, searching for early abnormalities before consumption onset. RESULTS: For the first time, abnormalities in MEG functional networks and higher dysexecutive and impulsivity profiles were detected in alcohol-naïve adolescents who two years later became binge drinkers. Concretely, fBD exhibit a distinctive pattern of beta band hyperconnectivity among crucial regions of inhibitory control networks, positively correlated with behavioral traits and future alcohol intake rate. CONCLUSIONS: These findings strongly support the idea of early neurobiological vulnerabilities for substances consumption initiation, with inhibitory functional networks' abnormalities as a relevant neurophysiological marker of subjects at risk- we hypothesize this profile is due to neurodevelopmental and neurobiological differences involving cognitive control networks and neurotransmission pathways.
BACKGROUND AND AIMS: Adolescent Binge drinking has become an increasing health and social concern, which cause several detrimental consequences for brain integrity. However, research on neurophysiological traits of vulnerability for binge drinking predisposition is limited at this time. In this work, we conducted a two-year longitudinal study with magnetoencephalography (MEG) over a cohort of initially alcohol-naive adolescents with the purpose of characterize inhibitory cortical networks' anomalies prior to alcohol consumption onset in those youths who will transit into binge drinkers years later. METHODS: Sixty-seven participant's inhibitory functional networks, and dysexecutive/impulsivity traits were measured by means of inhibitory task (go/no-go) and questionnaires battery. After a follow-up period of two years, we evaluated their alcohol consumption habits, sub-dividing them in two groups according to their alcohol intake patterns: future binge drinkers (fBD): n = 22; future Light/non-drinkers (fLD): n = 17. We evaluated whole-brain and seed-based functional connectivity profiles, as well as its correlation with impulsive and dysexecutive behaviours, searching for early abnormalities before consumption onset. RESULTS: For the first time, abnormalities in MEG functional networks and higher dysexecutive and impulsivity profiles were detected in alcohol-naïve adolescents who two years later became binge drinkers. Concretely, fBD exhibit a distinctive pattern of beta band hyperconnectivity among crucial regions of inhibitory control networks, positively correlated with behavioral traits and future alcohol intake rate. CONCLUSIONS: These findings strongly support the idea of early neurobiological vulnerabilities for substances consumption initiation, with inhibitory functional networks' abnormalities as a relevant neurophysiological marker of subjects at risk- we hypothesize this profile is due to neurodevelopmental and neurobiological differences involving cognitive control networks and neurotransmission pathways.
Authors: Luis F Antón-Toro; Ricardo Bruña; Alberto Del Cerro-León; Danylyna Shpakivska; Patricia Mateos-Gordo; Claudia Porras-Truque; Raquel García-Gómez; Fernando Maestú; Luis Miguel García-Moreno Journal: Addict Biol Date: 2022-07 Impact factor: 4.093