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Literature DB >> 33245103

Helicobacter pylori-Induced TLR9 Activation and Injury Are Associated With the Virulence-Associated Adhesin HopQ.

Samuel D R Dooyema^1,2, Uma S Krishna³, John T Loh³, Giovanni Suarez³, Timothy L Cover^1,3,4, Richard M Peek^1,3.

Abstract

Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma. The H. pylori cancer-associated cag pathogenicity island (cag-PAI) encodes a type IV secretion system (T4SS), which translocates microbial DNA and activates TLR9; however, most cag-PAI+-infected persons do not develop cancer and cag-PAI-independent regulators of pathogenesis, including strain-specific adhesins, remain understudied. We defined the relationships between H. pylori HopQ adhesin allelic type, gastric injury, and TLR9 activation. Type I hopQ alleles were significantly associated with magnitude of injury, cag-T4SS function, and TLR9 activation. Genetic deletion of hopQ significantly decreased H. pylori-induced TLR9 activation, implicating this adhesin in H. pylori-mediated disease.

Entities: Chemical

Keywords: zzm321990 Helicobacter pylorizzm321990 ; HopQ; TLR9; gastric cancer; secretion systems

Mesh：

Substances：

Year: 2021 PMID： 33245103 PMCID： PMC8280490 DOI： 10.1093/infdis/jiaa730

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

15 in total

1. Quantitative detection of Helicobacter pylori gene expression in vivo and relationship to gastric pathology.

Authors: R M Peek; L J van Doorn; J P Donahue; K T Tham; C Figueiredo; M J Blaser; G G Miller
Journal: Infect Immun Date: 2000-10 Impact factor: 3.441

Review 2. The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling.

Authors: Steffen Backert; Rainer Haas; Markus Gerhard; Michael Naumann
Journal: Curr Top Microbiol Immunol Date: 2017 Impact factor: 4.291

3. Two different families of hopQ alleles in Helicobacter pylori.

Authors: Ping Cao; Timothy L Cover
Journal: J Clin Microbiol Date: 2002-12 Impact factor: 5.948

4. Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils.

Authors: Rekha Loganathan; Mehnaz Nazeer; Vaishnavi Goda; Panneer Devaraju; Mohammed Ali; Premkumar Karunakaran; Megala Jayaraman
Journal: Hum Immunol Date: 2016-12-16 Impact factor: 2.850

Review 5. Helicobacter pylori and gastric cancer: factors that modulate disease risk.

Authors: Lydia E Wroblewski; Richard M Peek; Keith T Wilson
Journal: Clin Microbiol Rev Date: 2010-10 Impact factor: 26.132

6. Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells.

Authors: Kazuyuki Yokoyama; Hideaki Higashi; Susumu Ishikawa; Yumiko Fujii; Satoshi Kondo; Hiroyuki Kato; Takeshi Azuma; Akihiro Wada; Toshiya Hirayama; Hiroyuki Aburatani; Masanori Hatakeyama
Journal: Proc Natl Acad Sci U S A Date: 2005-06-24 Impact factor: 11.205

Review 7. Pathobiology of Helicobacter pylori-Induced Gastric Cancer.

Authors: Manuel Amieva; Richard M Peek
Journal: Gastroenterology Date: 2015-09-16 Impact factor: 22.682

8. TLR9 activation suppresses inflammation in response to Helicobacter pylori infection.

Authors: Matthew G Varga; M Blanca Piazuelo; Judith Romero-Gallo; Alberto G Delgado; Giovanni Suarez; Morgan E Whitaker; Uma S Krishna; Rachna V Patel; Eric P Skaar; Keith T Wilson; Holly M S Algood; Richard M Peek
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2016-10-06 Impact factor: 4.052