Daniele A Fagundes1,2, Liliam V Leonel2, Luis E Fernandez-Outon2,3, José D Ardisson2, Raquel G Dos Santos1. 1. Unidade de Radiobiologia, Centro de Desenvolvimento da Tecnologia Nuclear, Av. Presidente Antônio Carlos, 6627, Belo Horizonte, 31270-901, Brazil. 2. Serviço de Nanotecnologia, Centro de Desenvolvimento da Tecnologia Nuclear, Belo Horizonte, 31270-901, Brazil. 3. Departamento de Física, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
Abstract
Aim: Evaluation of the biocompatibility and radiosensitizer potential of citrate-coated cobalt (cit-CF) and nickel (cit-NF) ferrite nanoparticles (NPs). Materials & methods: Normal fibroblast and breast cancer cells were treated with different concentrations of citrate-coated ferrite NPs (cit-NPs) and irradiated with a cobalt-60 source at doses of 1 and 3 Gy. After 24 h, cell metabolism, morphology alterations and nanoparticle uptake were evaluated. Results: Cit-CF and cit-NF NPs showed no toxicity to normal cells up to 250 and 100 μg.ml-1, respectively. Combination of cit-NP and ionizing radiation resulted in up to fivefold increase in the radiation therapeutic efficacy against breast cancer cells. Conclusion: Cit-CF and cit-NF NPs are suitable candidates for application as breast cancer cell radiosensitizers.
Aim: Evaluation of the biocompatibility and radiosensitizer potential of citrate-coated cobalt (cit-CF) and nickel (cit-NF) ferrite nanoparticles (NPs). Materials & methods: Normal fibroblast and breast cancer cells were treated with different concentrations of citrate-coated ferrite NPs (cit-NPs) and irradiated with a cobalt-60 source at doses of 1 and 3 Gy. After 24 h, cell metabolism, morphology alterations and nanoparticle uptake were evaluated. Results:Cit-CF and cit-NF NPs showed no toxicity to normal cells up to 250 and 100 μg.ml-1, respectively. Combination of cit-NP and ionizing radiation resulted in up to fivefold increase in the radiation therapeutic efficacy against breast cancer cells. Conclusion:Cit-CF and cit-NF NPs are suitable candidates for application as breast cancer cell radiosensitizers.
Entities:
Keywords:
biocompatibility; breast cancer; nanobiotechnology; nanostructured magnetic ferrites; radiosensitizers
Authors: Zaira Gadzhimagomedova; Vladimir Polyakov; Ilia Pankin; Vera Butova; Daria Kirsanova; Mikhail Soldatov; Darya Khodakova; Anna Goncharova; Elizaveta Mukhanova; Anna Belanova; Aleksey Maksimov; Alexander Soldatov Journal: Int J Mol Sci Date: 2021-12-02 Impact factor: 5.923