Urinary prostaglandin E2 excretion in renal allotransplantation in man.

The urinary prostaglandin E2 excretion was measured daily for 28 days in 15 patients (10 men and 5 women) after renal allotransplantation. Patients with acute oliguric renal failure immediately after the transplantation showed high urinary PGE2 concentrations, but no or minimal increase in the total excretion rates. The median PGE2 excretion was 211 micrograms/24 h after establishment of stable renal function, but with great individual variations. Rejection crises were characterized by a two-fold increase in PGE2 excretion, with a subsequent fall induced by the steroid treatment. The PGE2 excretion correlated better with urinary sodium excretion than diuresis.