Jin Li1, Yang Zhou1,2, Xinxin Wang2, Meijuan Zhou3, Xi Chen3, Kuan Luan4. 1. Automation College, Harbin Engineering University, Harbin, 150001, Heilongjiang, China. 2. Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, 150001, Heilongjiang, China. 3. School of Information and Communications Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China. 4. Automation College, Harbin Engineering University, Harbin, 150001, Heilongjiang, China. luankuan@hrbeu.edu.cn.
Abstract
PURPOSE: To apply a multi-objective radiomics model based on pre-operative magnetic resonance imaging (MRI) for improving diagnostic accuracy of LN metastasis in rectal cancer patients. METHODS: This study consisted of 91 patients diagnosed with rectal cancer from April 2018 to March 2019. All patients underwent rectal MRI before surgery without any other treatment. Clinical data, subjective radiologist assessments, and radiomic features of LNs were obtained. A total of 1409 radiomic features were extracted from T2WI LN images. Multi-objective optimization with the iterative multi-objective immune algorithm (IMIA) was used to select radiomic features to build prediction models. Predictive performances of radiomic, radiologist, and combined radiomic and radiologist models were assessed for accuracy by receiver operating characteristics (ROC) curves. RESULTS: For the radiologist analysis, heterogeneity was the only significant independent predictor of LN status. The sensitivity, specificity, and accuracy of the subjective radiologist analysis were 72.09%, 73.81%, and 78.12%, respectively. The sensitivity, specificity, and accuracy of the solitary radiomic model consisting of 10 features were 89.81%, 82.57%, and 87.77%, respectively. The sensitivity, specificity, and accuracy of the combined model, which consisted of 12 radiomic and radiologist features, were 92.23%, 84.69%, and 89.88%, respectively. The combined model had the best prediction performance with an AUC of 0.94. CONCLUSIONS: The multi-objective radiomics model based on T2WI images was very useful in predicting pre-operative LN status in rectal cancer patients.
PURPOSE: To apply a multi-objective radiomics model based on pre-operative magnetic resonance imaging (MRI) for improving diagnostic accuracy of LN metastasis in rectal cancerpatients. METHODS: This study consisted of 91 patients diagnosed with rectal cancer from April 2018 to March 2019. All patients underwent rectal MRI before surgery without any other treatment. Clinical data, subjective radiologist assessments, and radiomic features of LNs were obtained. A total of 1409 radiomic features were extracted from T2WI LN images. Multi-objective optimization with the iterative multi-objective immune algorithm (IMIA) was used to select radiomic features to build prediction models. Predictive performances of radiomic, radiologist, and combined radiomic and radiologist models were assessed for accuracy by receiver operating characteristics (ROC) curves. RESULTS: For the radiologist analysis, heterogeneity was the only significant independent predictor of LN status. The sensitivity, specificity, and accuracy of the subjective radiologist analysis were 72.09%, 73.81%, and 78.12%, respectively. The sensitivity, specificity, and accuracy of the solitary radiomic model consisting of 10 features were 89.81%, 82.57%, and 87.77%, respectively. The sensitivity, specificity, and accuracy of the combined model, which consisted of 12 radiomic and radiologist features, were 92.23%, 84.69%, and 89.88%, respectively. The combined model had the best prediction performance with an AUC of 0.94. CONCLUSIONS: The multi-objective radiomics model based on T2WI images was very useful in predicting pre-operative LN status in rectal cancerpatients.
Entities:
Keywords:
Lymph nodes; Magnetic resonance imaging; Multi-objective radiomics; Rectal cancer
Authors: Søren R Rafaelsen; Claus Dam; Chris Vagn-Hansen; Jakob Møller; Hans B Rahr; Mikkel Sjöström; Jan Lindebjerg; Torben Frøstrup Hansen; Malene Roland Vils Pedersen Journal: Curr Oncol Date: 2022-02-13 Impact factor: 3.109