Literature DB >> 33241114

WNT: an unexpected tumor suppressor in medulloblastoma.

Branavan Manoranjan1, Ashley A Adile2, Chitra Venugopal3, Sheila K Singh2,3.   

Abstract

Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 and 4 MB.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Medulloblastoma; WNT; beta-catenin; brain tumor-initiating cell

Year:  2020        PMID： 33241114      PMCID： PMC7671060          DOI： 10.1080/23723556.2020.1834903

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum.

Authors:  Yanxin Pei; Sonja N Brun; Shirley L Markant; William Lento; Paul Gibson; Makoto M Taketo; Marco Giovannini; Richard J Gilbertson; Robert J Wechsler-Reya
Journal:  Development       Date:  2012-03-29       Impact factor: 6.868

2.  Experimental Evolution to Study Virus Emergence.

Authors:  Nathan D Grubaugh; Kristian G Andersen
Journal:  Cell       Date:  2017-03-23       Impact factor: 41.582

3.  Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.

Authors:  Travis L Biechele; Rima M Kulikauskas; Rachel A Toroni; Olivia M Lucero; Reyna D Swift; Richard G James; Nick C Robin; David W Dawson; Randall T Moon; Andy J Chien
Journal:  Sci Signal       Date:  2012-01-10       Impact factor: 8.192

4.  β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancer.

Authors:  E R M Bakker; E Hoekstra; P F Franken; W Helvensteijn; C H M van Deurzen; W van Veelen; E J Kuipers; R Smits
Journal:  Oncogene       Date:  2012-10-08       Impact factor: 9.867

5.  Regulation of cerebral cortical size by control of cell cycle exit in neural precursors.

Authors:  Anjen Chenn; Christopher A Walsh
Journal:  Science       Date:  2002-07-19       Impact factor: 47.728

6.  Paracrine Wnt signaling both promotes and inhibits human breast tumor growth.

Authors:  Jennifer L Green; Justin La; Kyu W Yum; Payal Desai; Luo-Wei Rodewald; Xiaomei Zhang; Mathias Leblanc; Roeland Nusse; Michael T Lewis; Geoffrey M Wahl
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-04       Impact factor: 11.205

Review 7.  Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.

Authors:  Vijay Ramaswamy; Marc Remke; Eric Bouffet; Simon Bailey; Steven C Clifford; Francois Doz; Marcel Kool; Christelle Dufour; Gilles Vassal; Till Milde; Olaf Witt; Katja von Hoff; Torsten Pietsch; Paul A Northcott; Amar Gajjar; Giles W Robinson; Laetitia Padovani; Nicolas André; Maura Massimino; Barry Pizer; Roger Packer; Stefan Rutkowski; Stefan M Pfister; Michael D Taylor; Scott L Pomeroy
Journal:  Acta Neuropathol       Date:  2016-04-04       Impact factor: 17.088
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.