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Literature DB >> 33241113

Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis.

Miharu Maeda¹, Yukie Komatsu¹, Kota Saito¹.

Abstract

How ER exit sites disassemble during mitosis is not well understood. Transport ANd Golgi Organization 1 (TANGO1, also known as MIA3), a cargo receptor originally identified for collagens, acts as a hub for ER exit site disassembly under the control of Casein Kinase 1 (CK1)-mediated phosphorylation and Protein Phosphatase 1 (PP1)-mediated dephosphorylation. Impaired dephosphorylation during mitosis induces ER exit site disassembly.

Entities: CellLine Species

Keywords: CK1; COPII; PP1; Sec16; Secretion; TANGO1; mitosis

Year: 2020 PMID： 33241113 PMCID： PMC7671029 DOI： 10.1080/23723556.2020.1832420

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

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References

6 in total

1. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites.

Authors: Kota Saito; Mei Chen; Fred Bard; Shenghong Chen; Huilin Zhou; David Woodley; Roman Polischuk; Randy Schekman; Vivek Malhotra
Journal: Cell Date: 2009-03-06 Impact factor: 41.582

Review 2. Not just a cargo receptor for large cargoes; an emerging role of TANGO1 as an organizer of ER exit sites.

Authors: Kota Saito; Miharu Maeda
Journal: J Biochem Date: 2019-08-01 Impact factor: 3.387

3. Distinct isoform-specific complexes of TANGO1 cooperatively facilitate collagen secretion from the endoplasmic reticulum.

Authors: Miharu Maeda; Kota Saito; Toshiaki Katada
Journal: Mol Biol Cell Date: 2016-07-13 Impact factor: 4.138

Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis.

1. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites.

Review 2. Not just a cargo receptor for large cargoes; an emerging role of TANGO1 as an organizer of ER exit sites.

3. Distinct isoform-specific complexes of TANGO1 cooperatively facilitate collagen secretion from the endoplasmic reticulum.

4. TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.

5. TANGO1 assembles into rings around COPII coats at ER exit sites.

6. Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export.