Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cancer metastasis: selectable traits without genetic constraints.

Literature DB >> 33241112

Cancer metastasis: selectable traits without genetic constraints.

Abstract

Widely metastatic cancers progress rapidly despite sharing genetic drivers with the primary tumor that seeds them. Our recent work indicates that metastatic pancreatic cancers evolve unique metabolic adaptations that are not genetically encoded. These adaptations harness niche-refined nutrients, such as hepatic glucose, to fuel malignant metaboloepigenetic programs that support widespread metastatic outgrowth.

Entities: Disease

Keywords: Cancer; chromatin; epigenetics; metabolism; metastasis

Year: 2020 PMID： 33241112 PMCID： PMC7670998 DOI： 10.1080/23723556.2020.1825910

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

8 in total

1. Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases.

Authors: Matthew E Bechard; Anna E Word; Amanda V Tran; Xiaojing Liu; Jason W Locasale; Oliver G McDonald
Journal: Oncogene Date: 2018-05-30 Impact factor: 9.867

Review 2. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer.

Authors: Christopher J Halbrook; Costas A Lyssiotis
Journal: Cancer Cell Date: 2017-01-09 Impact factor: 31.743

3. Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.

Authors: Jae-Seok Roe; Chang-Il Hwang; Tim D D Somerville; Joseph P Milazzo; Eun Jung Lee; Brandon Da Silva; Laura Maiorino; Hervé Tiriac; C Megan Young; Koji Miyabayashi; Dea Filippini; Brianna Creighton; Richard A Burkhart; Jonathan M Buscaglia; Edward J Kim; Jean L Grem; Audrey J Lazenby; James A Grunkemeyer; Michael A Hollingsworth; Paul M Grandgenett; Mikala Egeblad; Youngkyu Park; David A Tuveson; Christopher R Vakoc
Journal: Cell Date: 2017-07-27 Impact factor: 41.582

4. Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis.

Authors: Oliver G McDonald; Xin Li; Tyler Saunders; Rakel Tryggvadottir; Samantha J Mentch; Marc O Warmoes; Anna E Word; Alessandro Carrer; Tal H Salz; Sonoko Natsume; Kimberly M Stauffer; Alvin Makohon-Moore; Yi Zhong; Hao Wu; Kathryn E Wellen; Jason W Locasale; Christine A Iacobuzio-Donahue; Andrew P Feinberg
Journal: Nat Genet Date: 2017-01-16 Impact factor: 38.330

5. MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.

Authors: Carrie A Stoltzman; Mohan R Kaadige; Christopher W Peterson; Donald E Ayer
Journal: J Biol Chem Date: 2011-09-09 Impact factor: 5.157

6. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.

Authors: Carrie A Stoltzman; Christopher W Peterson; Kevin T Breen; Deborah M Muoio; Andrew N Billin; Donald E Ayer
Journal: Proc Natl Acad Sci U S A Date: 2008-05-05 Impact factor: 11.205

7. ATP-citrate lyase links cellular metabolism to histone acetylation.

Authors: Kathryn E Wellen; Georgia Hatzivassiliou; Uma M Sachdeva; Thi V Bui; Justin R Cross; Craig B Thompson
Journal: Science Date: 2009-05-22 Impact factor: 47.728

8. Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis.

Authors: Matthew E Bechard; Rana Smalling; Akimasa Hayashi; Yi Zhong; Anna E Word; Sydney L Campbell; Amanda V Tran; Vivian L Weiss; Christine Iacobuzio-Donahue; Kathryn E Wellen; Oliver G McDonald
Journal: Nat Commun Date: 2020-08-13 Impact factor: 14.919

8 in total

1 in total

Review 1. The biology of pancreatic cancer morphology.

Authors: Oliver G McDonald
Journal: Pathology Date: 2021-12-03 Impact factor: 5.306

1 in total