Literature DB >> 33241111

OTULIN couples WNT signaling to resistance in triple-negative breast cancer.

Wei Wang1,2,3, Zhao-Hui Wu1,2,3.   

Abstract

Oncogenic Wnt/β-catenin activation promotes cancer development and drug resistance to cancer treatments. We recently revealed an underlying mechanism linking linear ubiquitination with Wnt/β-catenin activation upon genotoxic treatments. We showed that ABL1 (ABL proto-oncogene 1)-dependent phosphorylation of OTULIN (OTU deubiquitinase with linear linkage specificity) upon DNA damage drives β-catenin activation which promotes drug resistance in triple-negative breast cancer.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  DNA damage; OTULIN; drug resistance; linear ubiquitination; β-catenin

Year:  2020        PMID： 33241111      PMCID： PMC7671033          DOI： 10.1080/23723556.2020.1825904

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer.

Authors:  A Singh; J Settleman
Journal:  Oncogene       Date:  2010-06-07       Impact factor: 9.867

2.  A receptor for eating mitochondria.

Authors:  Naotada Ishihara; Noboru Mizushima
Journal:  Dev Cell       Date:  2009-07       Impact factor: 12.270

3.  Functional interaction between DNA-PK and c-Abl in response to DNA damage.

Authors:  S Kharbanda; P Pandey; S Jin; S Inoue; A Bharti; Z M Yuan; R Weichselbaum; D Weaver; D Kufe
Journal:  Nature       Date:  1997-04-17       Impact factor: 49.962

4.  Senescence-associated reprogramming promotes cancer stemness.

Authors:  Maja Milanovic; Dorothy N Y Fan; Dimitri Belenki; J Henry M Däbritz; Zhen Zhao; Yong Yu; Jan R Dörr; Lora Dimitrova; Dido Lenze; Ines A Monteiro Barbosa; Marco A Mendoza-Parra; Tamara Kanashova; Marlen Metzner; Katharina Pardon; Maurice Reimann; Andreas Trumpp; Bernd Dörken; Johannes Zuber; Hinrich Gronemeyer; Michael Hummel; Gunnar Dittmar; Soyoung Lee; Clemens A Schmitt
Journal:  Nature       Date:  2017-12-20       Impact factor: 49.962

5.  Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Authors:  Georg Emons; Melanie Spitzner; Sebastian Reineke; Janneke Möller; Noam Auslander; Frank Kramer; Yue Hu; Tim Beissbarth; Hendrik A Wolff; Margret Rave-Fränk; Elisabeth Heßmann; Jochen Gaedcke; B Michael Ghadimi; Steven A Johnsen; Thomas Ried; Marian Grade
Journal:  Mol Cancer Res       Date:  2017-08-15       Impact factor: 5.852

6.  Activation of Wnt signaling promotes olaparib resistant ovarian cancer.

Authors:  Tomomi M Yamamoto; Alexandra McMellen; Zachary L Watson; Jennifer Aguilera; Rebecca Ferguson; Elmar Nurmemmedov; Tanay Thakar; George-Lucian Moldovan; Hyunmin Kim; Diana M Cittelly; Annette M Joglar; Elyse P Brennecke; Heidi Wilson; Kian Behbakht; Matthew J Sikora; Benjamin G Bitler
Journal:  Mol Carcinog       Date:  2019-06-10       Impact factor: 4.784

7.  Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.

Authors:  Veronique Schaeffer; Masato Akutsu; Michael H Olma; Ligia C Gomes; Masato Kawasaki; Ivan Dikic
Journal:  Mol Cell       Date:  2014-04-10       Impact factor: 17.970

8.  USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization.

Authors:  Chenming Wu; Kuntian Luo; Fei Zhao; Ping Yin; Ying Song; Min Deng; Jinzhou Huang; Yuping Chen; Lei Li; SeungBaek Lee; JungJin Kim; Qin Zhou; Xinyi Tu; Somaira Nowsheen; Qifeng Luo; Xiumei Gao; Zhenkun Lou; Zhongmin Liu; Jian Yuan
Journal:  Cell Death Differ       Date:  2018-06-04       Impact factor: 15.828

9.  Molecular basis and regulation of OTULIN-LUBAC interaction.

Authors:  Paul R Elliott; Sofie V Nielsen; Paola Marco-Casanova; Berthe Katrine Fiil; Kirstin Keusekotten; Niels Mailand; Stefan M V Freund; Mads Gyrd-Hansen; David Komander
Journal:  Mol Cell       Date:  2014-04-10       Impact factor: 19.328

10.  The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.

Authors:  Elena Rivkin; Stephanie M Almeida; Derek F Ceccarelli; Yu-Chi Juang; Teresa A MacLean; Tharan Srikumar; Hao Huang; Wade H Dunham; Ryutaro Fukumura; Gang Xie; Yoichi Gondo; Brian Raught; Anne-Claude Gingras; Frank Sicheri; Sabine P Cordes
Journal:  Nature       Date:  2013-05-24       Impact factor: 49.962
  10 in total
  1 in total

Review 1.  Post-Translational Modifications of Deubiquitinating Enzymes: Expanding the Ubiquitin Code.

Authors:  Yanfeng Wang; Feng Wang
Journal:  Front Pharmacol       Date:  2021-06-10       Impact factor: 5.810
  1 in total

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