Literature DB >> 33241110

A single-molecule view of telomerase regulation at telomeres.

Pascal Chartrand1, Agnel Sfeir2.   

Abstract

Telomerase plays a key role in the immortalization of cancer cells by maintaining telomeres length. Using single-molecule imaging of telomerase RNA molecules in cancer cells, we recently reported novel insights into the role of Cajal bodies in telomerase biogenesis and the regulation of telomerase recruitment to telomeres.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Telomerase; live-cell imaging; telomeres

Year:  2020        PMID： 33241110      PMCID： PMC7671040          DOI： 10.1080/23723556.2020.1818537

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  A Dengue Vaccine.

Authors:  Anna P Durbin
Journal:  Cell       Date:  2016-06-30       Impact factor: 41.582

2.  Localization of ASH1 mRNA particles in living yeast.

Authors:  E Bertrand; P Chartrand; M Schaefer; S M Shenoy; R H Singer; R M Long
Journal:  Mol Cell       Date:  1998-10       Impact factor: 17.970

3.  POT1 as a terminal transducer of TRF1 telomere length control.

Authors:  Diego Loayza; Titia De Lange
Journal:  Nature       Date:  2003-05-25       Impact factor: 49.962

4.  Telomerase RNA accumulates in Cajal bodies in human cancer cells.

Authors:  Yusheng Zhu; Rebecca L Tomlinson; Andrew A Lukowiak; Rebecca M Terns; Michael P Terns
Journal:  Mol Biol Cell       Date:  2003-10-03       Impact factor: 4.138

5.  The POT1-TPP1 telomere complex is a telomerase processivity factor.

Authors:  Feng Wang; Elaine R Podell; Arthur J Zaug; Yuting Yang; Paul Baciu; Thomas R Cech; Ming Lei
Journal:  Nature       Date:  2007-01-21       Impact factor: 69.504

6.  TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.

Authors:  Eladio Abreu; Elena Aritonovska; Patrick Reichenbach; Gaël Cristofari; Brad Culp; Rebecca M Terns; Joachim Lingner; Michael P Terns
Journal:  Mol Cell Biol       Date:  2010-04-19       Impact factor: 5.069

7.  Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation.

Authors:  Hadrien Laprade; Emmanuelle Querido; Michael Joseph Smith; David Guérit; Hannah Crimmins; Dimitri Conomos; Emilie Pourret; Pascal Chartrand; Agnel Sfeir
Journal:  Mol Cell       Date:  2020-06-03       Impact factor: 19.328

Review 8.  Human telomerase: biogenesis, trafficking, recruitment, and activation.

Authors:  Jens C Schmidt; Thomas R Cech
Journal:  Genes Dev       Date:  2015-06-01       Impact factor: 11.361

9.  Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.

Authors:  P Gu; Y Wang; K K Bisht; L Wu; L Kukova; E M Smith; Y Xiao; S M Bailey; M Lei; J Nandakumar; S Chang
Journal:  Oncogene       Date:  2016-11-21       Impact factor: 9.867

Review 10.  The enigma of excessively long telomeres in cancer: lessons learned from rare human POT1 variants.

Authors:  Yi Gong; Amanda J Stock; Yie Liu
Journal:  Curr Opin Genet Dev       Date:  2020-03-08       Impact factor: 4.665
  10 in total

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