Literature DB >> 33241105

RPA, RFWD3 and BRCA2 at stalled forks: a balancing act.

Haohui Duan1,2, Shailja Pathania1,2.   

Abstract

We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee fork repair. These findings provide new insights into the workings of BRCA1 and BRCA2 in the stalled fork repair pathway.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  BRCA1; BRCA2; MRE11; RFWD3; RPA ubiquitination; SMARCAL1; replication stress

Year:  2020        PMID： 33241105      PMCID： PMC7671022          DOI： 10.1080/23723556.2020.1801089

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  BRCA1 is required for postreplication repair after UV-induced DNA damage.

Authors:  Shailja Pathania; Jenna Nguyen; Sarah J Hill; Ralph Scully; Guillaume O Adelmant; Jarrod A Marto; Jean Feunteun; David M Livingston
Journal:  Mol Cell       Date:  2011-09-29       Impact factor: 17.970

2.  Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

Authors:  Katharina Schlacher; Nicole Christ; Nicolas Siaud; Akinori Egashira; Hong Wu; Maria Jasin
Journal:  Cell       Date:  2011-05-13       Impact factor: 41.582

3.  The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.

Authors:  H Putaala; R Soininen; P Kilpeläinen; J Wartiovaara; K Tryggvason
Journal:  Hum Mol Genet       Date:  2001-01-01       Impact factor: 6.150

4.  RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.

Authors:  Andrew E H Elia; David C Wang; Nicholas A Willis; Alexander P Boardman; Ildiko Hajdu; Richard O Adeyemi; Elizabeth Lowry; Steven P Gygi; Ralph Scully; Stephen J Elledge
Journal:  Mol Cell       Date:  2015-10-15       Impact factor: 17.970

5.  Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

Authors:  Arun Mouli Kolinjivadi; Vincenzo Sannino; Anna De Antoni; Karina Zadorozhny; Mairi Kilkenny; Hervé Técher; Giorgio Baldi; Rong Shen; Alberto Ciccia; Luca Pellegrini; Lumir Krejci; Vincenzo Costanzo
Journal:  Mol Cell       Date:  2017-07-27       Impact factor: 17.970

6.  Replication fork stability confers chemoresistance in BRCA-deficient cells.

Authors:  Arnab Ray Chaudhuri; Elsa Callen; Xia Ding; Ewa Gogola; Alexandra A Duarte; Ji-Eun Lee; Nancy Wong; Vanessa Lafarga; Jennifer A Calvo; Nicholas J Panzarino; Sam John; Amanda Day; Anna Vidal Crespo; Binghui Shen; Linda M Starnes; Julian R de Ruiter; Jeremy A Daniel; Panagiotis A Konstantinopoulos; David Cortez; Sharon B Cantor; Oscar Fernandez-Capetillo; Kai Ge; Jos Jonkers; Sven Rottenberg; Shyam K Sharan; André Nussenzweig
Journal:  Nature       Date:  2016-07-21       Impact factor: 49.962

7.  RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.

Authors:  Laura Feeney; Ivan M Muñoz; Christophe Lachaud; Rachel Toth; Paul L Appleton; Detlev Schindler; John Rouse
Journal:  Mol Cell       Date:  2017-06-01       Impact factor: 17.970
  7 in total
  1 in total

Review 1.  Genome Instability in Multiple Myeloma: Facts and Factors.

Authors:  Anna Y Aksenova; Anna S Zhuk; Artem G Lada; Irina V Zotova; Elena I Stepchenkova; Ivan I Kostroma; Sergey V Gritsaev; Youri I Pavlov
Journal:  Cancers (Basel)       Date:  2021-11-26       Impact factor: 6.639
  1 in total

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