Literature DB >> 3323887

Towards determination of the structure of the Saccharomyces cerevisiae a-factor: an acylated pentadecapeptide blocks a-factor activity.

J M Becker1, S Marcus, B Kundu, P Shenbagamurthi, F Naider.   

Abstract

Putative a-factor peptides YIIKGVFWADP, YIIKGVFWANP, YIIKGLFWADP, YIIKGLFWANP, YIIKGVFWDPA, and YIIKGVFWDPACVIA and several peptide derivatives were synthesized and were found to be inactive in growth arrest assays, yet they blocked the activity of biological a-factor. Antagonism was greatest with YIIKGVFWDPAC(palmitoyl)VIA. Thus, the structure of a-factor may be a lipopeptide resembling this palmitoylated pentadecapeptide.

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Year:  1987        PMID： 3323887      PMCID： PMC368084          DOI： 10.1128/mcb.7.11.4122-4124.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  14 in total

1.  Peptidal Sex Hormones Inducing Conjugation Tube Formation in Compatible Mating-Type Cells of Tremella mesenterica.

Authors:  Y Sakagami; M Yoshida; A Isogai; A Suzuki
Journal:  Science       Date:  1981-06-26       Impact factor: 47.728

2.  a-Factor from Saccharomyces cerevisiae: partial characterization of a mating hormone produced by cells of mating type a.

Authors:  R Betz; V L MacKay; W Duntze
Journal:  J Bacteriol       Date:  1977-11       Impact factor: 3.490

3.  Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae.

Authors:  R Betz; J W Crabb; H E Meyer; R Wittig; W Duntze
Journal:  J Biol Chem       Date:  1987-01-15       Impact factor: 5.157

4.  Structure and activation of the human N-ras gene.

Authors:  E Taparowsky; K Shimizu; M Goldfarb; M Wigler
Journal:  Cell       Date:  1983-09       Impact factor: 41.582

Review 5.  Protein localization and membrane traffic in yeast.

Authors:  R Schekman
Journal:  Annu Rev Cell Biol       Date:  1985

6.  Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway.

Authors:  D Julius; R Schekman; J Thorner
Journal:  Cell       Date:  1984-02       Impact factor: 41.582

Review 7.  Structure-activity relationships of the yeast alpha-factor.

Authors:  F Naider; J M Becker
Journal:  CRC Crit Rev Biochem       Date:  1986

8.  Purification and partial characterization of a factor, a mating hormone produced by mating-type-a cells from Saccharomyces cerevisiae.

Authors:  R Betz; W Duntze
Journal:  Eur J Biochem       Date:  1979-04

9.  Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

Authors:  R K Chan; C A Otte
Journal:  Mol Cell Biol       Date:  1982-01       Impact factor: 4.272

10.  Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

Authors:  S Powers; T Kataoka; O Fasano; M Goldfarb; J Strathern; J Broach; M Wigler
Journal:  Cell       Date:  1984-03       Impact factor: 41.582
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  4 in total

1.  AG alpha 1 is the structural gene for the Saccharomyces cerevisiae alpha-agglutinin, a cell surface glycoprotein involved in cell-cell interactions during mating.

Authors:  P N Lipke; D Wojciechowicz; J Kurjan
Journal:  Mol Cell Biol       Date:  1989-08       Impact factor: 4.272

2.  Degradation of a-factor by a Saccharomyces cerevisiae alpha-mating-type-specific endopeptidase: evidence for a role in recovery of cells from G1 arrest.

Authors:  S Marcus; C B Xue; F Naider; J M Becker
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

Review 3.  Fatty acylation of proteins.

Authors:  M F Schmidt
Journal:  Biochim Biophys Acta       Date:  1989-12-06

4.  Mating pheromones of the fission yeast Schizosaccharomyces pombe: purification and structural characterization of M-factor and isolation and analysis of two genes encoding the pheromone.

Authors:  J Davey
Journal:  EMBO J       Date:  1992-03       Impact factor: 11.598
  4 in total

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