Abdullah Kınar1, Şahin Ulu2, Abdulkadir Bucak2, Elif Kazan3. 1. Ear Nose and Throat Head and Neck Diseases, Afyonkarahisar State Hospital, Orhangazi Nedim Helvacıoğlu Blv. No:73, Afyonkarahisar, Turkey. abdullahkinar@gmail.com. 2. Department of Ear Nose and Throat Head and Neck Diseases, Afyonkarahisar Health Sciences University School of Medicine, Afyonkarahisar, Turkey. 3. Department of Internal Medicine, Afyonkarahisar Health Sciences University School of Medicine, Afyonkarahisar, Turkey.
Abstract
OBJECTIVE: Recent studies showed that the neutrophil-to-lymphocyte ratio (NLR) and that platelet-to-lymphocyte ratio (PLR) can be used as inflammatory markers in Bell's palsy. In this study, the aim is to investigate a novel inflammatory index, the Systemic Immune-Inflammation Index (SII), defined as SII = platelets × neutrophils/lymphocytes, in Bell's palsy patients. STUDY DESIGN: Retrospective. SETTING: Clinical research center. PATIENTS: The study included 88 Bell's palsy patients and 50 healthy controls. INTERVENTIONS: Patients diagnosed with Bell's palsy from 2010 to 2019 in a university hospital and an age- and sex-matched healthy control group were included in the study retrospectively. A complete blood count was performed for all participants. Magnetic resonance imaging was applied for Bell's palsy patients for the exclusion of other diagnoses. MAIN OUTCOME MEASURES: The CBC parameters were analyzed and hemoglobin, erythrocytes, leukocytes, neutrophils, lymphocytes, and platelet counts were measured. The PLR, NLR, and SII values were calculated with the formula. RESULTS: The patient group had higher neutrophil counts and higher SII and NLR values than the control group (p < 0.05). Also, SII value is a prognostic factor in Bell's palsy in our study. CONCLUSIONS: Bell's palsy has an inflammatory component. The SII value can indicate an inflammatory condition in these patients. It may be used as a marker and prognostic indicator in Bell's palsy.
OBJECTIVE: Recent studies showed that the neutrophil-to-lymphocyte ratio (NLR) and that platelet-to-lymphocyte ratio (PLR) can be used as inflammatory markers in Bell's palsy. In this study, the aim is to investigate a novel inflammatory index, the Systemic Immune-Inflammation Index (SII), defined as SII = platelets × neutrophils/lymphocytes, in Bell's palsypatients. STUDY DESIGN: Retrospective. SETTING: Clinical research center. PATIENTS: The study included 88 Bell's palsypatients and 50 healthy controls. INTERVENTIONS:Patients diagnosed with Bell's palsy from 2010 to 2019 in a university hospital and an age- and sex-matched healthy control group were included in the study retrospectively. A complete blood count was performed for all participants. Magnetic resonance imaging was applied for Bell's palsypatients for the exclusion of other diagnoses. MAIN OUTCOME MEASURES: The CBC parameters were analyzed and hemoglobin, erythrocytes, leukocytes, neutrophils, lymphocytes, and platelet counts were measured. The PLR, NLR, and SII values were calculated with the formula. RESULTS: The patient group had higher neutrophil counts and higher SII and NLR values than the control group (p < 0.05). Also, SII value is a prognostic factor in Bell's palsy in our study. CONCLUSIONS:Bell's palsy has an inflammatory component. The SII value can indicate an inflammatory condition in these patients. It may be used as a marker and prognostic indicator in Bell's palsy.