Sabine Krumm1,2, Manfred Berres3, Sasa L Kivisaari4, Andreas U Monsch1,2,5, Julia Reinhardt6,7, Maria Blatow6, Reto W Kressig1,2, Kirsten I Taylor5,8. 1. University Department of Geriatric Medicine FELIX PLATTER, Basel, Switzerland. 2. Faculty of Medicine, University of Basel, Basel, Switzerland. 3. Department of Mathematics and Technology, University of Applied Sciences Koblenz, Remagen, Germany. 4. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Aalto, Finland. 5. Faculty of Psychology, University of Basel, Basel, Switzerland. 6. Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland. 7. Division of Diagnostic and Interventional Neuroradiology, Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland. 8. Biomarkers and Translational Technology, Neuroscience and Rare Diseases (NRD), Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Abstract
OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.
OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.
Authors: Hélène Amieva; Mélanie Le Goff; Xavier Millet; Jean Marc Orgogozo; Karine Pérès; Pascale Barberger-Gateau; Hélène Jacqmin-Gadda; Jean François Dartigues Journal: Ann Neurol Date: 2008-11 Impact factor: 10.422
Authors: Kirsten I Taylor; Helen E Moss; Emmanuel A Stamatakis; Lorraine K Tyler Journal: Proc Natl Acad Sci U S A Date: 2006-05-15 Impact factor: 11.205