Muhammad Faisal1, Rahim Dhanani2, Sami Ullah2, Muhammad Abu Bakar3, Nabia Irfan4, Kashif Iqbal Malik2, Asif Loya5, Erovic M Boban6, Raza Hussain2, Arif Jamshed4. 1. Department of Head and Neck Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. muhammadfaisal@skm.org.pk. 2. Department of Head and Neck Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. 3. Department of Cancer Registry and Clinical Data Management, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. 4. Department of Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. 5. Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. 6. Department of Head and Neck Surgery, Evangelisches Krankenhaus, Vienna, Austria.
Abstract
OBJECTIVES: To analyze the factors predicting survival outcomes in treatment naïve oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS: A comprehensive review of 531 oral tongue carcinoma patients treated with upfront surgery followed by adjuvant radiotherapy or chemoradiotherapy was conducted from 2004-2018. RESULTS: The mean age of presentation was 53 years (11-86) with a male to female ratio of 1.3:1. The associated risk factors were smoking (21%), betel nut (16%), naswar (9%) and alcohol (1%). Most of the cases were either well (45.1%) or moderately (46.2%) differentiated. Surgery was performed in 164 patients alone while 368 were treated with surgery in combination with adjuvant modalities. Overall (OS) and disease free survival (DFS) were 66 and 71%, respectively, with a median follow up of 2.5 years. Cox regression analysis showed nodal positivity, increased depth of invasion (DOI) and higher lymph node ratio (LNR) as significant prognosticators impacting OS and DSS. CONCLUSION: Nodal volume, DOI and LNR are the most consistent predictors of poor outcome in OTSCC. Nodal positivity, depth of invasion > 5 mm and lymph node ratio > 0.04 adversely affect OS and DSS.
OBJECTIVES: To analyze the factors predicting survival outcomes in treatment naïve oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS: A comprehensive review of 531 oral tongue carcinomapatients treated with upfront surgery followed by adjuvant radiotherapy or chemoradiotherapy was conducted from 2004-2018. RESULTS: The mean age of presentation was 53 years (11-86) with a male to female ratio of 1.3:1. The associated risk factors were smoking (21%), betelnut (16%), naswar (9%) and alcohol (1%). Most of the cases were either well (45.1%) or moderately (46.2%) differentiated. Surgery was performed in 164 patients alone while 368 were treated with surgery in combination with adjuvant modalities. Overall (OS) and disease free survival (DFS) were 66 and 71%, respectively, with a median follow up of 2.5 years. Cox regression analysis showed nodal positivity, increased depth of invasion (DOI) and higher lymph node ratio (LNR) as significant prognosticators impacting OS and DSS. CONCLUSION: Nodal volume, DOI and LNR are the most consistent predictors of poor outcome in OTSCC. Nodal positivity, depth of invasion > 5 mm and lymph node ratio > 0.04 adversely affect OS and DSS.
Entities:
Keywords:
Depth of invasion; Lymph node ratio; Nodal volume; Oral tongue cancer; Predictors of survival
Authors: Volkert B Wreesmann; Nora Katabi; Frank L Palmer; Pablo H Montero; Jocelyn C Migliacci; Mithat Gönen; Diane Carlson; Ian Ganly; Jatin P Shah; Ronald Ghossein; Snehal G Patel Journal: Head Neck Date: 2015-10-30 Impact factor: 3.147
Authors: Joseph E Tota; William F Anderson; Charles Coffey; Joseph Califano; Wendy Cozen; Robert L Ferris; Maie St John; Ezra E W Cohen; Anil K Chaturvedi Journal: Oral Oncol Date: 2017-02-28 Impact factor: 5.972
Authors: Muhammad Faisal; Muhammad Abu Bakar; Albash Sarwar; Mohammad Adeel; Fatima Batool; Kashif Iqbal Malik; Arif Jamshed; Raza Hussain Journal: PLoS One Date: 2018-08-22 Impact factor: 3.240