Literature DB >> 33234838

The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury, and Sepsis: A Review of Pathophysiology.

Lauren S Kelly1, Dijoia B Darden, Brittany P Fenner, Philip A Efron, Alicia M Mohr.   

Abstract

ABSTRACT: Hematopoietic stem/progenitor cells (HSPC) have both unique and common responses following hemorrhage, injury, and sepsis. HSPCs from different lineages have a distinctive response to these "stress" signals. Inflammation, via the production of inflammatory factors, including cytokines, hormones, and interferons, has been demonstrated to impact the differentiation and function of HSPCs. In response to injury, hemorrhagic shock, and sepsis, cellular phenotypic changes and altered function occur, demonstrating the rapid response and potential adaptability of bone marrow hematopoietic cells. In this review, we summarize the pathophysiology of emergency myelopoiesis and the role of myeloid-derived suppressor cells, impaired erythropoiesis, as well as the mobilization of HSPCs from the bone marrow. Finally, we discuss potential therapeutic options to optimize HSPC function after severe trauma or infection.
Copyright © 2020 by the Shock Society.

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Year:  2021        PMID： 33234838      PMCID： PMC8141062          DOI： 10.1097/SHK.0000000000001699

Source DB:  PubMed          Journal:  Shock        ISSN： 1073-2322            Impact factor:   3.533


  161 in total

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2.  Stem cells, including a population of very small embryonic-like stem cells, are mobilized into peripheral blood in patients after skin burn injury.

Authors:  Justyna Drukała; Edyta Paczkowska; Magda Kucia; Elżbieta Młyńska; Andrzej Krajewski; Bogusław Machaliński; Zbigniew Madeja; Mariusz Z Ratajczak
Journal:  Stem Cell Rev Rep       Date:  2012-03       Impact factor: 5.739

3.  Chronic exposure to a TLR ligand injures hematopoietic stem cells.

Authors:  Brandt L Esplin; Tomoyuki Shimazu; Robert S Welner; Karla P Garrett; Lei Nie; Qingzhao Zhang; Mary Beth Humphrey; Qi Yang; Lisa A Borghesi; Paul W Kincade
Journal:  J Immunol       Date:  2011-03-25       Impact factor: 5.422

4.  Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.

Authors:  Bo Huang; Ping-Ying Pan; Qingsheng Li; Alice I Sato; David E Levy; Jonathan Bromberg; Celia M Divino; Shu-Hsia Chen
Journal:  Cancer Res       Date:  2006-01-15       Impact factor: 12.701

5.  Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling.

Authors:  Philip O Scumpia; Kindra M Kelly-Scumpia; Matthew J Delano; Jason S Weinstein; Alex G Cuenca; Samer Al-Quran; Ian Bovio; Shizuo Akira; Yutaro Kumagai; Lyle L Moldawer
Journal:  J Immunol       Date:  2010-02-03       Impact factor: 5.422

6.  Hematopoietic progenitor cells mobilize to the site of injury after trauma and hemorrhagic shock in rats.

Authors:  Chirag D Badami; David H Livingston; Ziad C Sifri; Francis J Caputo; Larissa Bonilla; Alicia M Mohr; Edwin A Deitch
Journal:  J Trauma       Date:  2007-09

7.  Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses.

Authors:  Ingo Fricke; Noweeda Mirza; Jakob Dupont; Craig Lockhart; Autumn Jackson; Ji-Hyun Lee; Jeffrey A Sosman; Dmitry I Gabrilovich
Journal:  Clin Cancer Res       Date:  2007-08-15       Impact factor: 12.531

8.  Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.

Authors:  Daisuke Nakada; Hideyuki Oguro; Boaz P Levi; Nicole Ryan; Ayumi Kitano; Yusuke Saitoh; Makiko Takeichi; George R Wendt; Sean J Morrison
Journal:  Nature       Date:  2014-01-23       Impact factor: 49.962

9.  Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.

Authors:  McKenzie K Hollen; Julie A Stortz; Dijoia Darden; Marvin L Dirain; Dina C Nacionales; Russell B Hawkins; Michael C Cox; Maria-Cecilia Lopez; Jaimar C Rincon; Ricardo Ungaro; Zhongkai Wang; Quran Wu; Babette Brumback; Marie-Pierre L Gauthier; Michael Kladde; Christiaan Leeuwenburgh; Mark Segal; Azra Bihorac; Scott Brakenridge; Frederick A Moore; Henry V Baker; Alicia M Mohr; Lyle L Moldawer; Philip A Efron
Journal:  Crit Care       Date:  2019-11-13       Impact factor: 9.097

10.  MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.

Authors:  Matthew J Delano; Philip O Scumpia; Jason S Weinstein; Dominique Coco; Srinivas Nagaraj; Kindra M Kelly-Scumpia; Kerri A O'Malley; James L Wynn; Svetlana Antonenko; Samer Z Al-Quran; Ryan Swan; Chun-Shiang Chung; Mark A Atkinson; Reuben Ramphal; Dmitry I Gabrilovich; Wesley H Reeves; Alfred Ayala; Joseph Phillips; Drake Laface; Paul G Heyworth; Michael Clare-Salzler; Lyle L Moldawer
Journal:  J Exp Med       Date:  2007-06-04       Impact factor: 14.307
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  4 in total

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2.  What's New in Shock, July 2021?

Authors:  Joseph Krocker; Jessica C Cardenas
Journal:  Shock       Date:  2021-07-01       Impact factor: 3.454

3.  Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.

Authors:  Dijoia B Darden; Juan C Mira; Maria-Cecilia Lopez; Julie A Stortz; Brittany P Fenner; Lauren S Kelly; Dina C Nacionales; Ashrita Budharaju; Tyler J Loftus; Henry V Baker; Frederick A Moore; Scott C Brakenridge; Lyle L Moldawer; Alicia M Mohr; Philip A Efron
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4.  An Early Myelosuppression in the Acute Mouse Sepsis Is Partly Outcome-Dependent.

Authors:  Tomasz Skirecki; Susanne Drechsler; Aldona Jeznach; Grażyna Hoser; Mohammad Jafarmadar; Jerzy Kawiak; Marcin F Osuchowski
Journal:  Front Immunol       Date:  2021-07-22       Impact factor: 7.561
  4 in total

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