| Literature DB >> 33234351 |
P Rv1, A Sundaresh1, M Karunyaa1, A Arun1, S Gayen2.
Abstract
The prevalence of mitotically heritable clonal random monoallelic expression of autosomal genes (aRME) remains controversial. Specifically, presence of clonal aRME is well supported in vitro but remains elusive in vivo. Here, we provide critical insights into this matter and discuss whether prevalent clonal aRME is natural or artifactual.Keywords: clonal monoallelic expression; dynamic monoallelic expression; epigenetic regulation; random monoallelic expression (RME); single-cell RNA-seq; transcriptional burst
Mesh：
Year: 2020 PMID： 33234351 DOI： 10.1016/j.tig.2020.10.011
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639