Literature DB >> 33234243

TAM receptors and their ligand-mediated activation: Role in atherosclerosis.

Bishuang Cai1, Canan Kasikara2.   

Abstract

TAM family tyrosine kinase receptors including Tyro3, Axl, and MerTK are the key efferocytosis receptors presenting on antigen-presenting cell that mediate the clearance of apoptotic cells. They are thought to regulate inflammatory diseases by modulating inflammatory response and efferocytosis. Recent studies have revealed novel roles of TAM receptors in the biosynthesis of specialized pro-resolving mediators (SPMs) and inflammation resolution. In this chapter, we discuss the central roles of TAM signaling in atherosclerosis focusing on their regulation in efferocytosis and inflammation resolution and highlight the unique therapeutic potential of SPMs in blocking the progression of atherosclerosis.
© 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Atherosclerosis; Efferocytosis; Inflammation resolution; MerTK cleavage; Specialized pro-resolving mediators; TAM

Year:  2020        PMID： 33234243      PMCID： PMC7971185          DOI： 10.1016/bs.ircmb.2020.09.001

Source DB:  PubMed          Journal:  Int Rev Cell Mol Biol        ISSN： 1937-6448            Impact factor:   6.813


  64 in total

1.  Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression.

Authors:  Canan Kasikara; Sushil Kumar; Stanley Kimani; Wen-I Tsou; Ke Geng; Viralkumar Davra; Ganapathy Sriram; Connor Devoe; Khanh-Quynh N Nguyen; Anita Antes; Allen Krantz; Grzegorz Rymarczyk; Andrzej Wilczynski; Cyril Empig; Bruce Freimark; Michael Gray; Kyle Schlunegger; Jeff Hutchins; Sergei V Kotenko; Raymond B Birge
Journal:  Mol Cancer Res       Date:  2017-02-09       Impact factor: 5.852

2.  MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis.

Authors:  Bishuang Cai; Edward B Thorp; Amanda C Doran; Brian E Sansbury; Mat J A P Daemen; Bernhard Dorweiler; Matthew Spite; Gabrielle Fredman; Ira Tabas
Journal:  J Clin Invest       Date:  2017-01-09       Impact factor: 14.808

3.  Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).

Authors:  Edward Thorp; Tomas Vaisar; Manikandan Subramanian; Lauren Mautner; Carl Blobel; Ira Tabas
Journal:  J Biol Chem       Date:  2011-08-02       Impact factor: 5.157

Review 4.  Macrophage death and defective inflammation resolution in atherosclerosis.

Authors:  Ira Tabas
Journal:  Nat Rev Immunol       Date:  2009-12-04       Impact factor: 53.106

5.  Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation.

Authors:  Nitu Tibrewal; Yi Wu; Veera D'mello; Reiko Akakura; Thaddeus C George; Brian Varnum; Raymond B Birge
Journal:  J Biol Chem       Date:  2007-11-26       Impact factor: 5.157

Review 6.  Pro-resolving lipid mediators are leads for resolution physiology.

Authors:  Charles N Serhan
Journal:  Nature       Date:  2014-06-05       Impact factor: 49.962

7.  CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.

Authors:  Amanda C Doran; Lale Ozcan; Bishuang Cai; Ze Zheng; Gabrielle Fredman; Christina C Rymond; Bernhard Dorweiler; Judith C Sluimer; Joanne Hsieh; George Kuriakose; Alan R Tall; Ira Tabas
Journal:  J Clin Invest       Date:  2017-10-03       Impact factor: 14.808

8.  Immunoproteasome subunit β5i regulates diet-induced atherosclerosis through altering MERTK-mediated efferocytosis in Apoe knockout mice.

Authors:  Jiawei Liao; Yunpeng Xie; Qiuyue Lin; Xiaolei Yang; Xiangbo An; Yunlong Xia; Jie Du; Feng Wang; Hui-Hua Li
Journal:  J Pathol       Date:  2020-01-14       Impact factor: 7.996

9.  Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increase Systemic Inflammation and Cardiovascular Disease.

Authors:  Romain A Colas; Patricia R Souza; Mary E Walker; Maudrian Burton; Zbigniew Zasłona; Annie M Curtis; Raquel M Marques; Jesmond Dalli
Journal:  Circ Res       Date:  2018-02-05       Impact factor: 17.367

Review 10.  Specialized pro-resolving mediators: endogenous regulators of infection and inflammation.

Authors:  Maria C Basil; Bruce D Levy
Journal:  Nat Rev Immunol       Date:  2015-12-21       Impact factor: 53.106
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