Aspasia Argyrou1, Serena Valsami2, Abraham Pouliakis3, Maria Gavalaki4, Antonis Aggelidis5, Vasiliki Voulgaridou6, Vasiliki Pliatsika6, Theofanis Adraktas4, Andreas Papachronis4, Chrysoula Alepi7, Vasiliki Giannopoulou7, Panagiotis Siourounis8, Sofia Tsagia8, Georges Martinis9, Eftihia Kontekaki9, Eleftheria Zervou10, Spiridon Koliofotis11, Elias Kyriakou11, Athina Mougiou12, Lempousi Dimitra12, Afrodite Chairopoulou13, Aggeliki Tsakania13, Maria Baka14, Ioanna Apostolidou14, Dimitra Moschandreou15, Anastasia Livada15, Marianna Politou2, Fragoula Roussinou2, Christina Pappa16, Vasiliki Koika16, Niki Vgontza5, Anthippi Gafou1, Ioanna Dendrinou5, Fotini Sakellaridi17, Lampothea Labrianou17, Zafeiria Alexandropoulou18, Vasiliki Sochali19, Kostas Malekas20, Areti Skordilaki21, Georgia Kakava22, Konstantinos Lebesopoulos23, Konstantinos Stamoulis24, Elisavet Grouzi15. 1. Agioi Anargyroi Hospital, Department of Blood Transfusion, Athens, Greece 2. National and Kapodistrian University of Athens, Aretaieion University Hospital, Medical School, Hematology Laboratory-Blood Bank Department, Athens, Greece 3. National and Kapodistrian University of Athens, Attikon University Hospital, Second Department of Pathology, Athens, Greece 4. Laiko General Hospital, Department of Blood Transfusion, Athens, Greece 5. Konstantopouleio-Neas Ionias General Hospital, Department of Blood Transfusion, Athens, Greece 6. AHEPA, University Hospital, Department of Blood Transfusion, Thessaloniki, Greece 7. General Hospital Tzaneio, Department of Blood Transfusion, Piraeus, Greece 8. Agios Panteleimon General Hospital of Nikaia, Department of Blood Transfusion, Athens, Greece 9. University Hospital, Department of Blood Transfusion, Alexandroupolis, Greece 10. University Hospital, Department of Blood Transfusion, Ioannina, Greece 11. Attikon University Hospital, Laboratory of Hematology and Blood Bank Unit, Athens, Greece 12. University Hospital, Blood Transfusion Center, Patras, Greece 13. Sismanogleio General Hospital, Department of Blood Transfusion, Athens, Greece 14. Thriasio General Hospital, Department of Blood Transfusion, Athens, Greece 15. Saint Savvas Oncology Hospital, Department of Blood Transfusion and Clinical Hemostasis, Athens, Greece 16. General Hospital, Department of Blood Transfusion, Korinthos, Greece 17. General Hospital, Department of Blood Transfusion, Rhodes, Greece 18. Asklipieio Voulas General Hospital, Department of Blood Transfusion, Athens, Greece 19. General Hospital, Department of Blood Transfusion, Giannitsa, Greece 20. General Hospital, Department of Blood Transfusion, Livadia, Greece 21. General Hospital, Department of Blood Transfusion, Chania, Greece 22. Pammakaristos General Hospital, Department of Blood Transfusion, Athens, Greece 23. Amalia Fleming General Hospital, Department of Blood Transfusion, Athens, Greece 24. Hellenic National Blood Transfusion Center, Athens, Greece
Abstract
Objective: Fresh frozen plasma (FFP) transfusion is widely used in modern clinical settings. Practices regarding its use vary due to lack of guidelines from randomized trials. The aim of this study was to assess both the current practices regarding FFP production, use, and wastage and the implementation of quality control (QC), female donor plasma production policies, and use of pharmaceutical hemostatic agents in Greece. Materials and Methods: The study was conducted during February-April 2018. For the first part of the study, data including FFP transfusion indication, hospital department, diagnosis, FFP units/transfusion episode, ABO compatibility, blood donor’s sex, and reasons for discarding were collected. For the second part, questionnaire data were analyzed. Results: According to data from 20 Greek hospitals, 12655 FFP units were transfused to 2700 patients during 5069 transfusion episodes in the studied period of time. Most patients were hospitalized in internal medicine, general surgery, and intensive care unit departments. Each patient received on average 4.69 units (2.5 units/episode). Transfusion requests were in accordance with international guidelines in 63.44% of cases and 99.04% of the units were given to ABO-identical patients. Main reasons for discarding included failure to meet quality requirements (30.06%), female donors (22.17%), and other causes (27.26%). Among 96.9% of all transfusion services across the country, 28.26% perform QC according to the directions of the European Directorate for the Quality of Medicines & Health Care and 68.83% discard plasma from female donors. Pharmaceutic hemostatic agents are used in 37.23% of the hospitals. Conclusion: This is the first national survey regarding FFP production and transfusion in Greece. Staff of internal medicine, general surgery, and ICU departments, where most FFP-transfused patients are hospitalized, should be regularly involved in training on contemporary transfusion guidelines. Upcoming centralization of FFP production and inventory management could help in homogenizing practices regarding FFP use and improve product quality. Strengthening the use of pharmaceutic hemostatic agents could improve patients’ management.
Objective: Fresh frozen plasma (FFP) transfusion is widely used in modern clinical settings. Practices regarding its use vary due to lack of guidelines from randomized trials. The aim of this study was to assess both the current practices regarding FFP production, use, and wastage and the implementation of quality control (QC), female donor plasma production policies, and use of pharmaceutical hemostatic agents in Greece. Materials and Methods: The study was conducted during February-April 2018. For the first part of the study, data including FFP transfusion indication, hospital department, diagnosis, FFP units/transfusion episode, ABO compatibility, blood donor’s sex, and reasons for discarding were collected. For the second part, questionnaire data were analyzed. Results: According to data from 20 Greek hospitals, 12655 FFP units were transfused to 2700 patients during 5069 transfusion episodes in the studied period of time. Most patients were hospitalized in internal medicine, general surgery, and intensive care unit departments. Each patient received on average 4.69 units (2.5 units/episode). Transfusion requests were in accordance with international guidelines in 63.44% of cases and 99.04% of the units were given to ABO-identical patients. Main reasons for discarding included failure to meet quality requirements (30.06%), female donors (22.17%), and other causes (27.26%). Among 96.9% of all transfusion services across the country, 28.26% perform QC according to the directions of the European Directorate for the Quality of Medicines & Health Care and 68.83% discard plasma from female donors. Pharmaceutic hemostatic agents are used in 37.23% of the hospitals. Conclusion: This is the first national survey regarding FFP production and transfusion in Greece. Staff of internal medicine, general surgery, and ICU departments, where most FFP-transfused patients are hospitalized, should be regularly involved in training on contemporary transfusion guidelines. Upcoming centralization of FFP production and inventory management could help in homogenizing practices regarding FFP use and improve product quality. Strengthening the use of pharmaceutic hemostatic agents could improve patients’ management.
Entities:
Keywords:
Aquired coagulopathies; Blood coagulation; Replacement therapies; Transfusion medicine
Authors: G Erdoes; A Koster; E Ortmann; M I Meesters; D Bolliger; E Baryshnikova; B Martinez Lopez De Arroyabe; A Ahmed; M D Lance; M Ranucci; C von Heymann; S Agarwal; H B Ravn Journal: Anaesthesia Date: 2020-07-17 Impact factor: 6.955
Authors: Daan P van den Brink; Mathijs R Wirtz; Ary Serpa Neto; Herbert Schöchl; Victor Viersen; Jan Binnekade; Nicole P Juffermans Journal: J Thromb Haemost Date: 2020-08-02 Impact factor: 5.824