| Literature DB >> 33232143 |
Fu Ye1, Qing Liu1, Ranran Cui1, Dekang Xu1, Yu Gao1, Haijun Chen1.
Abstract
We report herein diverse functionalization of tetrahydro-β-carbolines (THβCs) or tetrahydro-γ-carbolines (THγCs) via oxidative coupling rearrangement. The treatment of THβCs or THγCs with t-BuOOH (TBHP) afforded 3-peroxyindolenines, followed by HCl catalyzed indolation to form unexpected 2-indolyl-3-peroxyindolenines. Further rearrangement of these peroxides allows for rapid access to a skeletally diverse chemical library in good to excellent yields.Entities:
Year: 2020 PMID： 33232143 DOI： 10.1021/acs.joc.0c02351
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354