Literature DB >> 33229313

[The role of miRNA in kidney development].

Xiao Qi Zhao1, Ying Ao1, Hai Yun Chen1, Hui Wang1.   

Abstract

MicroRNAs (miRNAs) are endogenous small non-coding RNAs (19-25 nucleotides) that negatively regulate gene expression at the post transcriptional level by binding to complementary target sequences in the target mRNA. miRNAs play an important role in a wide range of biological processes, including organ development. Recent studies have shown that some miRNAs are highly expressed in the kidney and are closely related to kidney development and diseases, suggesting that miRNAs are important regulators in kidney physiology and pathology. This review will focus on the research progress of miRNA in kidney development, and discuss the role of miRNAs in the occurrence and development of renal dysplasia, which will provide a reference for the diagnosis and research of diseases related to kidney development.

Entities:  

Keywords:  diagnosis; kidney development; kidney dysplasia; mechanism; microRNAs

Mesh:

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Year:  2020        PMID: 33229313     DOI: 10.16288/j.yczz.20-112

Source DB:  PubMed          Journal:  Yi Chuan        ISSN: 0253-9772


  2 in total

1.  Cancer associated fibroblasts secreted exosomal miR-1290 contributes to prostate cancer cell growth and metastasis via targeting GSK3β.

Authors:  Shuo Wang; Yudong Cao; Jinchao Ma; Peng Du; Xiao Yang; Ziyi Yu; Yong Yang
Journal:  Cell Death Discov       Date:  2022-08-23

2.  A novel nine-microRNA-based model to improve prognosis prediction of renal cell carcinoma.

Authors:  Chen Xu; Hui Zeng; Junli Fan; Wenjie Huang; Xiaosi Yu; Shiqi Li; Fubing Wang; Xinghua Long
Journal:  BMC Cancer       Date:  2022-03-12       Impact factor: 4.430

  2 in total

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