Sari Mullola1, Jeanne Brooks-Gunn2, Marko Elovainio3, Christian Hakulinen4, Lisa M Schneper5, Daniel A Notterman6. 1. Columbia University, Teachers College, National Center for Children and Families (NCCF), Thorndike Hall 525 West 120th Street, Box 39 New York, NY 10027, USA; Tampere University, Faculty of Education and Culture, Main Campus Virta, Åkerlundinkatu 5, P.O. Box 700, FI-33014 Tampere University, Finland; University of Helsinki, Faculty of Educational Sciences, Siltavuorenpenger 5A, P.O. Box 9, 00014 University of Helsinki, Finland. Electronic address: sari.mullola@tuni.fi. 2. Columbia University, Teachers College, National Center for Children and Families (NCCF), Thorndike Hall 525 West 120th Street, Box 39 New York, NY 10027, USA; Columbia University, The College of Physicians and Surgeons, New York, NY 10027, USA. Electronic address: brooks-gunn@columbia.edu. 3. University of Helsinki, Medical Faculty, Department of Psychology and Logopedics, Helsinki, Finland; Institute for Health and Welfare, P.O. Box 30, 00370 Helsinki, Finland. Electronic address: marko.elovainio@helsinki.fi. 4. University of Helsinki, Medical Faculty, Department of Psychology and Logopedics, Helsinki, Finland. Electronic address: christian.hakulinen@helsinki.fi. 5. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: lweis@princeton.edu. 6. Princeton University, 219 Lewis Thomas Laboratory, Princeton, NJ 08544, USA. Electronic address: dan1@princeton.edu.
Abstract
BACKGROUND: We examined, (a) whether in early childhood exposure to risky family environment in different domains (socioeconomic, mental, parenting practices, health behavior, and child-related risks) and accumulatively across various domains (cumulative risk) is associated with child's problem behavior at age 9, and (b) whether the association is more pronounced in children carrying cumulative dopaminergic sensitizing genotype or living in low-income families. METHODS: Participants were 2,860 9-year old children (48% females; 48% Black) and their mothers from the 'Fragile Families and Child Wellbeing Study', a probability birth cohort from large U.S. cities. Mothers responded to questions on child's problem behavior (CBCL). Children responded to questions about their vandalism and substance use. RESULTS: Cumulative family risk was associated with higher internalizing and externalizing behavior and higher vandalism and substance use. All domain-specific risk clusters were associated with higher internalizing behavior and, with the exception of child-related risk, with higher externalizing behavior. Mental health risks, risky parenting practices, and risky health behavior were associated with higher vandalism. Risky parenting practices were associated with higher substance use. The associations were robust to adjustment for cumulative dopaminergic sensitizing genotype. No G x E interactions with dopaminergic genotype and family SES were observed. LIMITATIONS: Sample size was relatively small for genetic analysis and polygenic risk scores were not available. CONCLUSIONS: Exposure to cumulative psychosocial family risks from early childhood is associated with early indicators of problem behavior in adolescence.
BACKGROUND: We examined, (a) whether in early childhood exposure to risky family environment in different domains (socioeconomic, mental, parenting practices, health behavior, and child-related risks) and accumulatively across various domains (cumulative risk) is associated with child's problem behavior at age 9, and (b) whether the association is more pronounced in children carrying cumulative dopaminergic sensitizing genotype or living in low-income families. METHODS: Participants were 2,860 9-year old children (48% females; 48% Black) and their mothers from the 'Fragile Families and Child Wellbeing Study', a probability birth cohort from large U.S. cities. Mothers responded to questions on child's problem behavior (CBCL). Children responded to questions about their vandalism and substance use. RESULTS: Cumulative family risk was associated with higher internalizing and externalizing behavior and higher vandalism and substance use. All domain-specific risk clusters were associated with higher internalizing behavior and, with the exception of child-related risk, with higher externalizing behavior. Mental health risks, risky parenting practices, and risky health behavior were associated with higher vandalism. Risky parenting practices were associated with higher substance use. The associations were robust to adjustment for cumulative dopaminergic sensitizing genotype. No G x E interactions with dopaminergic genotype and family SES were observed. LIMITATIONS: Sample size was relatively small for genetic analysis and polygenic risk scores were not available. CONCLUSIONS: Exposure to cumulative psychosocial family risks from early childhood is associated with early indicators of problem behavior in adolescence.
Authors: Rosa M M de Almeida; Pier Francesco Ferrari; Stefano Parmigiani; Klaus A Miczek Journal: Eur J Pharmacol Date: 2005-12-05 Impact factor: 4.432
Authors: Katharina Pittner; Marinus H van Ijzendoorn; Lenneke R A Alink; Renate S M Buisman; Laura H C G C Compier-de Block; Lisa J M van den Berg; Bernet M Elzinga; Jolanda Lindenberg; Marieke S Tollenaar; Vincent P Diego; Marian J Bakermans-Kranenburg Journal: Dev Psychopathol Date: 2019-02
Authors: J M Najman; G M Williams; J Nikles; S Spence; W Bor; M O'Callaghan; R Le Brocque; M J Andersen; G J Shuttlewood Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2001-04 Impact factor: 4.328