Minjoung Monica Koo1, Ruth Swann2, Sean McPhail3, Gary A Abel4, Cristina Renzi5, Greg P Rubin6, Georgios Lyratzopoulos3. 1. University College London, 1-19 Torrington Place, London WC1E 6BT, UK; National Cancer Registration and Analysis Service, Public Health England, Wellington House, 133-155 Waterloo Road, London, SE1 8UG, UK. Electronic address: Monica.koo@ucl.ac.uk. 2. National Cancer Registration and Analysis Service, Public Health England, Wellington House, 133-155 Waterloo Road, London, SE1 8UG, UK; Cancer Research UK, 2 Redman Place, London, E20 1JQ, UK. 3. University College London, 1-19 Torrington Place, London WC1E 6BT, UK; National Cancer Registration and Analysis Service, Public Health England, Wellington House, 133-155 Waterloo Road, London, SE1 8UG, UK. 4. University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK. 5. University College London, 1-19 Torrington Place, London WC1E 6BT, UK. 6. Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Abstract
BACKGROUND: Pre-existing chronic conditions (morbidities) influence the diagnosis and management of cancer. The prevalence of specific morbidities in patients diagnosed with common and rarer cancers is inadequately described. METHODS: Using data from the English National Cancer Diagnosis Audit 2014, we studied 11 pre-existing morbidities recorded as yes/no items by participating general practitioners based on information included in primary care records. We examined the number and type of morbidities across socio-demographic and cancer site strata, and subsequently estimated observed and age/sex standardised prevalence of each morbidity by cancer. RESULTS: Over three-quarters (77 %; 11,429/14,774) of non-screen-detected patients had at least one chronic condition before diagnosis, while nearly half (47 %) had two or more. Hypertension (39 %) and physical disability (2%) were the most and least common conditions. Male, older and more socio-economically deprived patients were more likely to have at least one morbidity (p < 0.001 for all between variable group comparisons). For most morbidities, the standardised prevalence was similar across different cancers with a few exceptions, including respiratory disease prevalence being greatest among lung cancer patients and diabetes prevalence being greatest among liver, pancreatic, and endometrial cancer patients. CONCLUSIONS: Most cancer patients have at least one morbidity, while almost one in two have two or more. The findings highlight the need to take certain morbidity- and cancer-site combinations into account when examining associations between morbidity and cancer outcomes.
BACKGROUND: Pre-existing chronic conditions (morbidities) influence the diagnosis and management of cancer. The prevalence of specific morbidities in patients diagnosed with common and rarer cancers is inadequately described. METHODS: Using data from the English National Cancer Diagnosis Audit 2014, we studied 11 pre-existing morbidities recorded as yes/no items by participating general practitioners based on information included in primary care records. We examined the number and type of morbidities across socio-demographic and cancer site strata, and subsequently estimated observed and age/sex standardised prevalence of each morbidity by cancer. RESULTS: Over three-quarters (77 %; 11,429/14,774) of non-screen-detected patients had at least one chronic condition before diagnosis, while nearly half (47 %) had two or more. Hypertension (39 %) and physical disability (2%) were the most and least common conditions. Male, older and more socio-economically deprived patients were more likely to have at least one morbidity (p < 0.001 for all between variable group comparisons). For most morbidities, the standardised prevalence was similar across different cancers with a few exceptions, including respiratory disease prevalence being greatest among lung cancerpatients and diabetes prevalence being greatest among liver, pancreatic, and endometrial cancerpatients. CONCLUSIONS: Most cancerpatients have at least one morbidity, while almost one in two have two or more. The findings highlight the need to take certain morbidity- and cancer-site combinations into account when examining associations between morbidity and cancer outcomes.
Authors: Sarah McLachlan; Gemma Mansell; Tom Sanders; Sarah Yardley; Daniëlle van der Windt; Lucy Brindle; Carolyn Chew-Graham; Paul Little Journal: Fam Pract Date: 2015-06-22 Impact factor: 2.267
Authors: Margreet Lüchtenborg; Eva J A Morris; Daniela Tataru; Victoria H Coupland; Andrew Smith; Roger L Milne; Luc Te Marvelde; Deborah Baker; Jane Young; Donna Turner; Diane Nishri; Craig Earle; Lorraine Shack; Anna Gavin; Deirdre Fitzpatrick; Conan Donnelly; Yulan Lin; Bjørn Møller; David H Brewster; Andrew Deas; Dyfed W Huws; Ceri White; Janet Warlow; Jem Rashbass; Michael D Peake Journal: Thorax Date: 2017-10-27 Impact factor: 9.139
Authors: Nicolò Matteo Luca Battisti; Catherine A Welch; Michael Sweeting; Mark de Belder; John Deanfield; Clive Weston; Michael D Peake; David Adlam; Alistair Ring Journal: JACC CardioOncol Date: 2022-06-21
Authors: Victoria Hardy; Adelaide Yue; Stephanie Archer; Samuel William David Merriel; Matthew Thompson; Jon Emery; Juliet Usher-Smith; Fiona M Walter Journal: BMJ Open Date: 2022-01-24 Impact factor: 2.692
Authors: Laura Ashley; Saifuddin Kassim; Ian Kellar; Lisa Kidd; Frances Mair; Mike Matthews; Mollie Price; Daniel Swinson; Johanna Taylor; Galina Velikova; Jonathan Wadsley Journal: BMJ Open Date: 2022-02-22 Impact factor: 2.692