| Literature DB >> 33225746 |
Ming-Yang Chen1, Qing-Yi Xie2, Fan-Dong Kong2, Qing-Yun Ma2, Li-Man Zhou2, Jing-Zhe Yuan2, Hao-Fu Dai2,3, You-Gen Wu1, You-Xing Zhao2,3.
Abstract
Two new compounds named epipaxilline (1) and penerpene J (2) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC50 values of 31.5 and 9.5 μM, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC50 value of 14.7 μM.Entities:
Keywords: Indole-diterpenoid; Penicillium sp.; marine-derived fungus; protein phoshatases inhibitory activity
Year: 2020 PMID： 33225746 DOI： 10.1080/10286020.2020.1849150
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569