Sara J Arter1, Brian Tyler2, Jennifer McAllister3, Elizabeth Kiel4, Ayse Güler5, M Cameron Hay6. 1. Assistant Professor, Department of Nursing, Miami University, Hamilton, OH, USA. 2. Postdoctoral Fellow, Department of Anthropology, Miami University, Oxford, OH, USA. 3. Medical Director, West Chester Hospital Special Care Nursery; Medical Director, University of Cincinnati Newborn Nursery; Medical Director, Neonatal Opioid Withdrawal Syndrome Follow-Up Clinic, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. 4. Associate Professor, Department of Psychology, Miami University, Oxford, OH, USA. 5. PhD student, University of Cincinnati College of Nursing, Cincinnati, OH, USA. 6. Professor and Chair, Anthropology; Director, Global Health Research Innovation Center, Miami University, Oxford, OH, USA.
Abstract
PURPOSE: The purpose was to summarize evidence of long-term outcomes of children, 2 years and older, exposed to opioids in-utero. DESIGN: This was a systematic review. Studies were identified by searching the following electronic databases: PubMed, EBSCO HOST/Medline, and Web of Science. Articles were published between 1979 and 2019. METHODS: This systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis. Two sets of two independent reviewers extracted data and assessed study quality according to National Institutes of Health quality assessment tools. RESULTS: Forty-three articles met inclusion criteria. Synthesis of articles identified trends toward worse outcomes for children with in-utero opioid exposure in all areas, most notably related to academic success, behavior, cognition, hospitalizations, and vision. CONCLUSIONS: Findings reinforce the necessity of continued research in this area with improved study design. Despite limitations in the current body of evidence, findings from this review are vital knowledge for clinicians, because children exposed to opioids in-utero are clearly vulnerable to a wide variety of suboptimal health and developmental outcomes. CLINICAL RELEVANCE: Recognition of all outcomes across childhood associated with in-utero opioid exposure will inform improved identification and interventions tailored to the most pressing needs of affected children. Despite the need for continued research, there is sufficient evidence to necessitate close, individualized follow-up throughout childhood.
PURPOSE: The purpose was to summarize evidence of long-term outcomes of children, 2 years and older, exposed to opioids in-utero. DESIGN: This was a systematic review. Studies were identified by searching the following electronic databases: PubMed, EBSCO HOST/Medline, and Web of Science. Articles were published between 1979 and 2019. METHODS: This systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis. Two sets of two independent reviewers extracted data and assessed study quality according to National Institutes of Health quality assessment tools. RESULTS: Forty-three articles met inclusion criteria. Synthesis of articles identified trends toward worse outcomes for children with in-utero opioid exposure in all areas, most notably related to academic success, behavior, cognition, hospitalizations, and vision. CONCLUSIONS: Findings reinforce the necessity of continued research in this area with improved study design. Despite limitations in the current body of evidence, findings from this review are vital knowledge for clinicians, because children exposed to opioids in-utero are clearly vulnerable to a wide variety of suboptimal health and developmental outcomes. CLINICAL RELEVANCE: Recognition of all outcomes across childhood associated with in-utero opioid exposure will inform improved identification and interventions tailored to the most pressing needs of affected children. Despite the need for continued research, there is sufficient evidence to necessitate close, individualized follow-up throughout childhood.
Authors: Carla M Bann; Jamie E Newman; Brenda Poindexter; Katherine Okoniewski; Sara DeMauro; Scott A Lorch; Deanne Wilson-Costello; Namasivayam Ambalavanan; Myriam Peralta-Carcelen; Catherine Limperopoulos; Kushal Kapse; Jonathan M Davis; Michele Walsh; Stephanie Merhar Journal: Pediatr Res Date: 2022-08-30 Impact factor: 3.953
Authors: Gerbrich E van den Bosch; Dick Tibboel; Jurgen C de Graaff; Hanan El Marroun; Aad van der Lugt; Tonya White; Monique van Dijk Journal: Front Pediatr Date: 2022-05-11 Impact factor: 3.569