Literature DB >> 3322505

Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats.

K A O'Neill1, J M Liebman.   

Abstract

Injection of the specific N-methyl-D-aspartate (NMDA) antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), into the frontal cortex of rats, induced hyperactivity characterized by unique episodic darting behavior. This behavioral profile contrasts sharply with the ataxia and hyperactivity seen after intracerebroventricular CPP and other NMDA antagonists.

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Year:  1987        PMID： 3322505     DOI： 10.1016/0006-8993(87)91628-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Typical and atypical neuroleptics antagonize MK-801-induced locomotion and stereotypy in rats.

Authors:  D C Hoffman
Journal:  J Neural Transm Gen Sect       Date:  1992

2.  Effects of N-methyl-D-aspartate antagonism on spatial learning in mice.

Authors:  M Upchurch; J M Wehner
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Memory deficits induced by gamma-L-glutamyl-L-aspartate and D-2-amino-6-phosphonovalerate in a Y-maze avoidance task: relationship to NMDA receptor antagonism.

Authors:  C Mathis; J de Barry; A Ungerer
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

4.  Prefrontal stimulation of GABAA receptors counteracts the corticolimbic hyperactivity produced by NMDA antagonists in the prefrontal cortex of the rat.

Authors:  Alberto Del Arco; Giacomo Ronzoni; Francisco Mora
Journal:  Psychopharmacology (Berl)       Date:  2010-10-28       Impact factor: 4.530

5.  A comparison between the non-competitive NMDA antagonist dizocilpine (MK-801) and the competitive NMDA antagonist D-CPPene with regard to dopamine turnover and locomotor-stimulatory properties in mice.

Authors:  A Svensson; E Pileblad; M Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1991

6.  Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilizing microdialysis.

Authors:  B K Malhotra; M Lemaire; R J Sawchuk
Journal:  Pharm Res       Date:  1994-09       Impact factor: 4.200

7.  Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity.

Authors:  Alberto Del Arco; Gregorio Segovia; Francisco Mora
Journal:  Psychopharmacology (Berl)       Date:  2008-08-28       Impact factor: 4.530
  7 in total

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