BACKGROUND: The assessment of lymphovascular invasion (LVI) on the specimens of a transurethral resection of bladder tumors (TURBT) is very important for risk stratification and decision-making on further treatment for bladder cancer. OBJECTIVES: The present study aimed to identify clinical predictors associated with the risk of bladder cancer with LVI before a first TURBT. METHODS: A total of 291 patients underwent a first TURBT for bladder cancer at Toho University Sakura Medical Center between January 2012 and December 2016. We analyzed predictors of LVI based on data from 217 patients and predictors of high grade and ≥ pT1 tumors based on data from the medical records of 237 patients for comparison with LVI risk factors. RESULTS: Univariate analysis significantly associated LVI with episodes of gross hematuria, positive urinary cytology, and larger, non-papillary and sessile tumors. Multivariate analysis selected larger tumors [odds ratio (OR) 1.39; 95 % confidence interval (CI) 1.08-1.78; p = 0.01], and non-papillary (OR 10.05; 95% CI 3.75-26.91; p < 0.01) and sessile (OR 2.65; 95% CI 1.18-5.93; p = 0.02) tumors as significant predictors of LVI. Some predictors such as tumor size and non-papillary tumors overlapped between high-grade and ≥ pT1 bladder cancer. CONCLUSIONS: These predictors can help clinicians to identify patients with, or who are at high-risk for LVI before undergoing a first TURBT and to determine priorities for preoperative evaluation and scheduling consecutive treatments.
BACKGROUND: The assessment of lymphovascular invasion (LVI) on the specimens of a transurethral resection of bladder tumors (TURBT) is very important for risk stratification and decision-making on further treatment for bladder cancer. OBJECTIVES: The present study aimed to identify clinical predictors associated with the risk of bladder cancer with LVI before a first TURBT. METHODS: A total of 291 patients underwent a first TURBT for bladder cancer at Toho University Sakura Medical Center between January 2012 and December 2016. We analyzed predictors of LVI based on data from 217 patients and predictors of high grade and ≥ pT1 tumors based on data from the medical records of 237 patients for comparison with LVI risk factors. RESULTS: Univariate analysis significantly associated LVI with episodes of gross hematuria, positive urinary cytology, and larger, non-papillary and sessile tumors. Multivariate analysis selected larger tumors [odds ratio (OR) 1.39; 95 % confidence interval (CI) 1.08-1.78; p = 0.01], and non-papillary (OR 10.05; 95% CI 3.75-26.91; p < 0.01) and sessile (OR 2.65; 95% CI 1.18-5.93; p = 0.02) tumors as significant predictors of LVI. Some predictors such as tumor size and non-papillary tumors overlapped between high-grade and ≥ pT1 bladder cancer. CONCLUSIONS: These predictors can help clinicians to identify patients with, or who are at high-risk for LVI before undergoing a first TURBT and to determine priorities for preoperative evaluation and scheduling consecutive treatments.
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Authors: Matthew J Resnick; Meredith Bergey; Laurie Magerfleisch; John E Tomaszewski; S Bruce Malkowicz; Thomas J Guzzo Journal: BJU Int Date: 2010-09-29 Impact factor: 5.588
Authors: Hans-Martin Fritsche; Maximilian Burger; Robert S Svatek; Claudio Jeldres; Pierre I Karakiewicz; Giacomo Novara; Eila Skinner; Stefan Denzinger; Yves Fradet; Hendrik Isbarn; Patrick J Bastian; Bjoern G Volkmer; Francesco Montorsi; Wassim Kassouf; Derya Tilki; Wolfgang Otto; Umberto Capitanio; Jonathan I Izawa; Vincenzo Ficarra; Seth Lerner; Arthur I Sagalowsky; Mark Schoenberg; Ashish Kamat; Colin P Dinney; Yair Lotan; Shahrokh F Shariat Journal: Eur Urol Date: 2009-09-12 Impact factor: 20.096
Authors: Jeremy W Martin; Simone L Vernez; Yair Lotan; Ahmed Abdelhalim; Rahul Dutta; Ahmed Shokeir; Hassan Abol-Enein; Ahmed Mosbah; Mohamed Ghoneim; Ramy F Youssef Journal: World J Urol Date: 2018-05-14 Impact factor: 4.226