Somaye Fatahi1, Shakiba Shoaee Matin2, Mohammad Hassan Sohouli2, Mihnea-Alexandru Găman3, Pourya Raee4, Beheshteh Olang5, Vaani Kathirgamathamby6, Heitor O Santos7, Nathalia Sernizon Guimarães8, Farzad Shidfar9. 1. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran; Pediatric Gastroenterology, Hepatology, and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. 3. "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania. 4. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Pediatric Gastroenterology, Hepatology, and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Department of Medicine and Life Sciences, Kings College London, University of London, Strand, London, WC2R 2LS, United Kingdom. 7. School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil. 8. Department of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. 9. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address: shidfar.f@iums.ac.ir.
Abstract
BACKGROUND: A potential relationship between depression and the intake of dietary fiber has been hypothesized in several studies. However, no meta-analysis has been conducted so far to explore the association between these two variables. Hence, we designed the present meta-analysis to elucidate the relationship between the intake of dietary fiber and depression. METHODS: A comprehensive search was performed using the PubMed/Medline, Scopus, Web of Science and Google Scholar databases to identify any relevant studies published from inception to October 2019. Observational studies (cross-sectional and case-control) were included in the analysis. RESULTS: Pooled analysis from the random-effects model of four case-control studies revealed that the consumption of dietary fiber in patients with depression was significantly lower versus healthy controls (WMD: -1.41 mg/dl, 95 % CI: -2.32, -0.51, P = 0.002). No significant heterogeneity was demonstrated among the analyzed studies (I2 = 4.0 %, P = 0.37). By pooling 5 effect sizes of cross-sectional studies (with a total of 97,023 subjects), we demonstrated that a higher dietary consumption of fiber was associated with significantly lower odds of depression (OR = 0.76; 95 % CI: 0.64, 0.90; P = 0.010), with a low heterogeneity seen among the retrieved studies (I2 = 43.9 %; P = 0.12). CONCLUSION: An increased intake of total dietary fiber is associated with lower odds of depression. Further studies are needed to evaluate the relationship between the different types of dietary fiber and depression.
BACKGROUND: A potential relationship between depression and the intake of dietary fiber has been hypothesized in several studies. However, no meta-analysis has been conducted so far to explore the association between these two variables. Hence, we designed the present meta-analysis to elucidate the relationship between the intake of dietary fiber and depression. METHODS: A comprehensive search was performed using the PubMed/Medline, Scopus, Web of Science and Google Scholar databases to identify any relevant studies published from inception to October 2019. Observational studies (cross-sectional and case-control) were included in the analysis. RESULTS: Pooled analysis from the random-effects model of four case-control studies revealed that the consumption of dietary fiber in patients with depression was significantly lower versus healthy controls (WMD: -1.41 mg/dl, 95 % CI: -2.32, -0.51, P = 0.002). No significant heterogeneity was demonstrated among the analyzed studies (I2 = 4.0 %, P = 0.37). By pooling 5 effect sizes of cross-sectional studies (with a total of 97,023 subjects), we demonstrated that a higher dietary consumption of fiber was associated with significantly lower odds of depression (OR = 0.76; 95 % CI: 0.64, 0.90; P = 0.010), with a low heterogeneity seen among the retrieved studies (I2 = 43.9 %; P = 0.12). CONCLUSION: An increased intake of total dietary fiber is associated with lower odds of depression. Further studies are needed to evaluate the relationship between the different types of dietary fiber and depression.
Authors: José Francisco López-Gil; Iván Cavero-Redondo; Estela Jiménez-López; Bruno Bizzozero-Peroni; Alicia Saz-Lara; Arthur Eumann Mesas Journal: JAMA Netw Open Date: 2022-04-01