Literature DB >> 33217477

The RUNX1/RUNX1T1 network: translating insights into therapeutic options.

Laura E Swart1, Olaf Heidenreich2.   

Abstract

RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid leukemia. Seminal contributions by many different research groups have revealed a complex regulatory network promoting leukemic self-renewal and propagation. Perturbation of RUNX1/RUNX1T1 levels and its DNA binding affects chromatin accessibility and transcription factor occupation at multiple gene loci associated with changes in gene expression levels. Exploration of this transcriptional program by targeted RNAi screens uncovered a crucial role of RUNX1/RUNX1T1 in cell cycle progression by regulating CCND2. This dependency results in a high vulnerability toward inhibitors of CDK4 and CDK6 and suggests new avenues for therapeutic intervention against acute myeloid leukemia.
Copyright © 2020 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 33217477      PMCID： PMC7854360          DOI： 10.1016/j.exphem.2020.11.005

Source DB:  PubMed          Journal:  Exp Hematol        ISSN： 0301-472X            Impact factor:   3.084


  82 in total

1.  Recurrent cyclin D2 mutations in myeloid neoplasms.

Authors:  V Khanna; C A Eide; C E Tognon; J E Maxson; B Wilmot; D Bottomly; S McWeeney; D K Edwards V; B J Druker; J W Tyner
Journal:  Leukemia       Date:  2017-06-20       Impact factor: 11.528

2.  CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Authors:  John Anto Pulikkan; Mahesh Hegde; Hafiz Mohd Ahmad; Houda Belaghzal; Anuradha Illendula; Jun Yu; Kelsey O'Hagan; Jianhong Ou; Carsten Muller-Tidow; Scot A Wolfe; Lihua Julie Zhu; Job Dekker; John Hackett Bushweller; Lucio Hernán Castilla
Journal:  Cell       Date:  2018-06-28       Impact factor: 41.582

3.  Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1.

Authors:  Oren Ben-Ami; Dan Friedman; Dena Leshkowitz; Dalia Goldenberg; Kira Orlovsky; Niv Pencovich; Joseph Lotem; Amos Tanay; Yoram Groner
Journal:  Cell Rep       Date:  2013-09-19       Impact factor: 9.423

4.  The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

Authors:  Amit Mandoli; Abhishek A Singh; Koen H M Prange; Esther Tijchon; Marjolein Oerlemans; Rene Dirks; Menno Ter Huurne; Albertus T J Wierenga; Eva M Janssen-Megens; Kim Berentsen; Nilofar Sharifi; Bowon Kim; Filomena Matarese; Luan N Nguyen; Nina C Hubner; Nagesha A Rao; Emile van den Akker; Lucia Altucci; Edo Vellenga; Hendrik G Stunnenberg; Joost H A Martens
Journal:  Cell Rep       Date:  2016-11-15       Impact factor: 9.423

5.  ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Authors:  Cécile Thirant; Cathy Ignacimouttou; Cécile K Lopez; M'Boyba Diop; Lou Le Mouël; Clarisse Thiollier; Aurélie Siret; Phillipe Dessen; Zakia Aid; Julie Rivière; Philippe Rameau; Céline Lefebvre; Mehdi Khaled; Guy Leverger; Paola Ballerini; Arnaud Petit; Hana Raslova; Catherine L Carmichael; Benjamin T Kile; Eric Soler; John D Crispino; Christian Wichmann; Françoise Pflumio; Jürg Schwaller; William Vainchenker; Camille Lobry; Nathalie Droin; Olivier A Bernard; Sébastien Malinge; Thomas Mercher
Journal:  Cancer Cell       Date:  2017-03-13       Impact factor: 31.743

6.  Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.

Authors:  Xiaorong Gu; Zhenbo Hu; Quteba Ebrahem; John S Crabb; Reda Z Mahfouz; Tomas Radivoyevitch; John W Crabb; Yogen Saunthararajah
Journal:  J Biol Chem       Date:  2014-04-02       Impact factor: 5.157

7.  RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.

Authors:  Justin Loke; Salam A Assi; Maria Rosaria Imperato; Anetta Ptasinska; Pierre Cauchy; Yura Grabovska; Natalia Martinez Soria; Manoj Raghavan; H Ruud Delwel; Peter N Cockerill; Olaf Heidenreich; Constanze Bonifer
Journal:  Cell Rep       Date:  2017-05-23       Impact factor: 9.423

8.  Subtype-specific regulatory network rewiring in acute myeloid leukemia.

Authors:  Salam A Assi; Maria Rosaria Imperato; Daniel J L Coleman; Anna Pickin; Sandeep Potluri; Anetta Ptasinska; Paulynn Suyin Chin; Helen Blair; Pierre Cauchy; Sally R James; Joaquin Zacarias-Cabeza; L Niall Gilding; Andrew Beggs; Sam Clokie; Justin C Loke; Phil Jenkin; Ash Uddin; Ruud Delwel; Stephen J Richards; Manoj Raghavan; Michael J Griffiths; Olaf Heidenreich; Peter N Cockerill; Constanze Bonifer
Journal:  Nat Genet       Date:  2018-11-12       Impact factor: 38.330

9.  The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells.

Authors:  Natalia Martinez; Bettina Drescher; Heidemarie Riehle; Claire Cullmann; Hans-Peter Vornlocher; Arnold Ganser; Gerhard Heil; Alfred Nordheim; Jürgen Krauter; Olaf Heidenreich
Journal:  BMC Cancer       Date:  2004-08-06       Impact factor: 4.430

10.  Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.

Authors:  Anetta Ptasinska; Salam A Assi; Natalia Martinez-Soria; Maria Rosaria Imperato; Jason Piper; Pierre Cauchy; Anna Pickin; Sally R James; Maarten Hoogenkamp; Dan Williamson; Mengchu Wu; Daniel G Tenen; Sascha Ott; David R Westhead; Peter N Cockerill; Olaf Heidenreich; Constanze Bonifer
Journal:  Cell Rep       Date:  2014-09-18       Impact factor: 9.423
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  4 in total

1.  The Prognostic Significance of the BIN1 and CCND2 Gene in Adult Patients with Acute Myeloid Leukemia.

Authors:  Xinwen Zhang; Hao Xiong; Jialin Duan; Xiaomin Chen; Yang Liu; Chunlan Huang
Journal:  Indian J Hematol Blood Transfus       Date:  2021-08-05       Impact factor: 0.915

Review 2.  RUNX1T1 function in cell fate.

Authors:  Nan Hu; Linqing Zou; Cheng Wang; Guoqi Song
Journal:  Stem Cell Res Ther       Date:  2022-07-28       Impact factor: 8.079

3.  Whole-transcriptome bioinformatics revealed HTRA3, KRT8, KRT17, and RHEX as novel targets in acute myeloid leukaemia.

Authors:  Omar S El-Masry; Abeer A Alshwareb; Fatimah H Alnasser; Sukainah G Al Mishaal; Khaldoon M Alsamman
Journal:  J Taibah Univ Med Sci       Date:  2022-03-10

4.  RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy.

Authors:  Ekaterina I Romanova; Anatoliy V Zubritskiy; Anna V Lioznova; Adewale J Ogunleye; Vasily A Golotin; Anna A Guts; Andreas Lennartsson; Oleg N Demidov; Yulia A Medvedeva
Journal:  Int J Mol Sci       Date:  2022-09-27       Impact factor: 6.208
  4 in total

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