Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.

Literature DB >> 33216373

Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.

Santosh L Saraf¹, Xu Zhang¹, Binal N Shah¹, Rasha Raslan¹, Bamidele O Tayo², James P Lash³, Nora Franceschini⁴, Victor R Gordeuk¹.

Abstract

Sickle cell disease (SCD) and apolipoprotein L1 (APOL1) G1/G2 variants increase chronic kidney disease (CKD) risk in African Americans by poorly understood mechanisms. We applied bioinformatics to identify new candidate genes associated with SCD-related CKD. An interaction network demonstrated APOA1 connecting haemoglobin subunit β (HBB) and APOL1 with 36 other candidate genes. Gene expression revealed upregulation of engulfment and cell motility 1 (ELMO1) and downregulation of APOA1 in the kidney cortex of SCD versus non-SCD mice. Analysis of candidate genes identified ELMO1 rs10951509 to be associated with albuminuria and APOA1 rs11216132 with haemoglobinuria in patients with SCD. A bioinformatic approach highlights ELMO1 and APOA1 as potentially associated with SCD nephropathy.

Entities: Chemical

Keywords: APOA1; APOL1; ELMO1; kidney disease; sickle cell disease

Mesh：

Substances：

Year: 2020 PMID： 33216373 PMCID： PMC8084902 DOI： 10.1111/bjh.17224

Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998

21 in total

1. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.

Authors: Christopher S Carlson; Michael A Eberle; Mark J Rieder; Qian Yi; Leonid Kruglyak; Deborah A Nickerson
Journal: Am J Hum Genet Date: 2003-12-15 Impact factor: 11.025

2. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.

Authors: Da Wei Huang; Brad T Sherman; Richard A Lempicki
Journal: Nat Protoc Date: 2009 Impact factor: 13.491

Review 3. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.

Authors: Barry I Freedman; Jeffrey B Kopp; Carl D Langefeld; Giulio Genovese; David J Friedman; George W Nelson; Cheryl A Winkler; Donald W Bowden; Martin R Pollak
Journal: J Am Soc Nephrol Date: 2010-08-05 Impact factor: 10.121

4. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.

Authors: Catherine K Hathaway; Albert S Chang; Ruriko Grant; Hyung-Suk Kim; Victoria J Madden; C Robert Bagnell; J Charles Jennette; Oliver Smithies; Masao Kakoki
Journal: Proc Natl Acad Sci U S A Date: 2016-02-08 Impact factor: 11.205

5. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease.

Authors: Xu Zhang; Wei Zhang; Shwu-Fan Ma; Ankit A Desai; Santosh Saraf; Galina Miasniakova; Adelina Sergueeva; Tatiana Ammosova; Min Xu; Sergei Nekhai; Taimur Abbasi; Nancy G Casanova; Martin H Steinberg; Clinton T Baldwin; Paola Sebastiani; Josef T Prchal; Rick Kittles; Joe G N Garcia; Roberto F Machado; Victor R Gordeuk
Journal: Circulation Date: 2014-02-10 Impact factor: 29.690

6. Dysregulation of ubiquitin-proteasome pathway and apolipoprotein A metabolism in sickle cell disease-related pulmonary arterial hypertension.

Authors: Fatima Anjum; Jason Lazar; James Soh; Maher Albitar; Satish Gowda; M Mahmood Hussain; Raj Wadgaonkar
Journal: Pulm Circ Date: 2013-12 Impact factor: 3.017

Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.

1. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.

2. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.

Review 3. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.

4. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.

5. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease.

6. Dysregulation of ubiquitin-proteasome pathway and apolipoprotein A metabolism in sickle cell disease-related pulmonary arterial hypertension.

7. Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC.

Review 8. The molecular arms race between African trypanosomes and humans.

9. Prevalence and awareness of CKD among African Americans: the Jackson Heart Study.

10. Hemoglobin is a co-factor of human trypanosome lytic factor.

Review 1. The Roles of Fatty Acids and Apolipoproteins in the Kidneys.

2. Reduction in the rate and improvement in the prognosis of COVID-19 in haematological patients over time.