Karen Müller Ramalho1, Sandra Ribeiro Cunha2, Flavia Gonçalves3, Gustavo Silva Escudeiro3, Carolina Steiner-Oliveira4, Anna Carolina Rato Tempestini Horliana5, Carlos de Paula Eduardo6. 1. Universidade Ibirapuera, Av. Interlagos, 1329, São Paulo, SP, Brazil; Universidade de São Paulo, Faculdade de Odontologia, Av. Professor Lineu Prestes, 2227, São Paulo, SP, Brazil. Electronic address: karenramalho@hotmail.com. 2. University of Iowa, College of Dentistry, 801 Newton Rd, Iowa City, IA, United States. 3. Universidade Ibirapuera, Av. Interlagos, 1329, São Paulo, SP, Brazil. 4. Universidade Estadual de Campinas, Faculdade de Odontologia, Av. Limeira, 901, Piracicaba, SP, Brazil. 5. Postgraduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil. 6. Universidade de São Paulo, Faculdade de Odontologia, Av. Professor Lineu Prestes, 2227, São Paulo, SP, Brazil.
Abstract
BACKGROUND: Herpes Simplex Virus Type 1 (HSV-1) is one of the most widespread infections that can effect the orofacial region. Recurrent infection is considered a life-long oral health problem, leading to pain, discomfort, and social restriction due to esthetic features when active. Effective therapies are needed. This study aimed to compare photodynamic therapy (PDT), Topical Acyclovir (AC), and the association of both in the healing process and self-reported symptomologies of HSV-1 recurrences. METHODS: Patients were randomly assigned into 3 groups (n = 25): PDT (low-power laser, 660 nm, 40 mW, 120 J/cm2, 4.8 J, 120 s per point) and methylene blue (0.005 %) as photosensitizer; AC (5%); PDT + AC.Data concerning lesion size, healing time, and self-reported healing parameters, such as pain, tingling, and edema were taken every day up to complete healing for all studied groups. RESULTS: There was no significant difference in healing time and pain between groups. AC group showed a significant minor reduction of the lesion compared to the AC-PDT group on day 1. Regarding edema and tingling, the comparison of treatments showed a statistical difference only on day 1, where PDT showed better results. CONCLUSION: With all the limitations of this study, it can be concluded that only on day 1 PDT showed positive effects in the treatment of herpes lesions in comparison to AC.
RCT Entities:
BACKGROUND:Herpes Simplex Virus Type 1 (HSV-1) is one of the most widespread infections that can effect the orofacial region. Recurrent infection is considered a life-long oral health problem, leading to pain, discomfort, and social restriction due to esthetic features when active. Effective therapies are needed. This study aimed to compare photodynamic therapy (PDT), Topical Acyclovir (AC), and the association of both in the healing process and self-reported symptomologies of HSV-1 recurrences. METHODS:Patients were randomly assigned into 3 groups (n = 25): PDT (low-power laser, 660 nm, 40 mW, 120 J/cm2, 4.8 J, 120 s per point) and methylene blue (0.005 %) as photosensitizer; AC (5%); PDT + AC.Data concerning lesion size, healing time, and self-reported healing parameters, such as pain, tingling, and edema were taken every day up to complete healing for all studied groups. RESULTS: There was no significant difference in healing time and pain between groups. AC group showed a significant minor reduction of the lesion compared to the AC-PDT group on day 1. Regarding edema and tingling, the comparison of treatments showed a statistical difference only on day 1, where PDT showed better results. CONCLUSION: With all the limitations of this study, it can be concluded that only on day 1 PDT showed positive effects in the treatment of herpes lesions in comparison to AC.
Authors: Ana Waleska Pessoa Barros; Pedro Henrique da Hora Sales; Paulo Goberlânio de Barros Silva; Ana Claudia Amorim Gomes; Alessandra Albuquerque Tavares Carvalho; Jair Carneiro Leão Journal: Lasers Med Sci Date: 2022-10-10 Impact factor: 2.555