Literature DB >> 33212218

Essential Tremor - A Cerebellar Driven Disorder?

Mohamed Fasil Ibrahim1, Jessica C Beevis2, Ruth M Empson2.   

Abstract

Abnormal tremors are the most common of all movement disorders. In this review we focus on the role of the cerebellum in Essential Tremor, a highly debilitating but poorly treated movement disorder. We propose a variety of mechanisms driving abnormal burst firing of deep cerebellar nuclei neurons as a key initiator of tremorgenesis in Essential Tremor. Targetting these mechanisms may generate more effective treatments for Essential Tremor.
Copyright © 2020. Published by Elsevier Ltd.

Entities:  

Keywords:  Purkinje neuron; deep cerebellar nuclei; essential tremor

Year:  2020        PMID： 33212218     DOI： 10.1016/j.neuroscience.2020.11.002

Source DB:  PubMed          Journal:  Neuroscience        ISSN： 0306-4522            Impact factor:   3.590


  7 in total

1.  Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients.

Authors:  Jiaxin Peng; Nannan Li; Junying Li; Liren Duan; Chaolan Chen; Yan Zeng; Jing Xi; Yi Jiang; Rong Peng
Journal:  J Neurol       Date:  2022-01-30       Impact factor: 4.849

2.  Essential Tremor: Five New Things.

Authors:  Abhishek Lenka; Sanjay Pandey
Journal:  Neurol Clin Pract       Date:  2022-04

3.  Locus coeruleus degeneration and cerebellar gray matter changes in essential tremor.

Authors:  Dayao Lv; Cheng Zhou; Jiali Pu; Jinyu Lu; Gaohua Zhao; Luyan Gu; Xiaojun Guan; Tao Guo; Xiaojun Xu; Minming Zhang; Jun Tian; Xinzhen Yin; Baorong Zhang; Guohua Zhao; Yaping Yan
Journal:  J Neurol       Date:  2022-10-04       Impact factor: 6.682

4.  Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.

Authors:  Thomas A W Bolton; Dimitri Van De Ville; Jean Régis; Tatiana Witjas; Nadine Girard; Marc Levivier; Constantin Tuleasca
Journal:  Front Aging Neurosci       Date:  2022-05-23       Impact factor: 5.702

Review 5.  A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms.

Authors:  Kohei Segawa; Yukari Blumenthal; Yuki Yamawaki; Gen Ohtsuki
Journal:  Biology (Basel)       Date:  2021-01-06

Review 6.  Closing the Loop With Cortical Sensing: The Development of Adaptive Deep Brain Stimulation for Essential Tremor Using the Activa PC+S.

Authors:  Tomasz M Fra Czek; Benjamin I Ferleger; Timothy E Brown; Margaret C Thompson; Andrew J Haddock; Brady C Houston; Jeffrey G Ojemann; Andrew L Ko; Jeffrey A Herron; Howard J Chizeck
Journal:  Front Neurosci       Date:  2021-12-08       Impact factor: 4.677

Review 7.  Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology.

Authors:  Md Sorwer Alam Parvez; Gen Ohtsuki
Journal:  Brain Sci       Date:  2022-03-10
  7 in total

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