Tariq N Aladily1, Wiam Khreisat2, Omar Ashukhaibi3, Sohaib M Alkhatib4, Hassan Annab5, Musleh S Tarawneh6, Thaher S Salman6, Hussam Abu Farsakh7, Randa Mahgoub8, Nadwa Bustami8, Ahmad T Mansour8, Saif Aldeen AlRyalat9, Abdalla S Abbadi10, Feras Al-Fararjeh10, Maher Sughayer11, Omar Jaber11. 1. Department of Pathology, The University of Jordan, Amman, Jordan. Electronic address: tnaladily@ju.edu.jo. 2. Directorate of Al-Bashir Hospital Laboratories and National Center for Forensic Medicine, Ministry of Health, Amman, Jordan. 3. Pathology, Princess Iman Research and Laboratory Sciences Center, King Hussein Medical Center, Amman, Jordan. 4. Department of Pathology and Laboratory Medicine, Jordan University of Science and Technology, Irbid, Jordan. 5. Pathology and Laboratory Medicine, Jordan Hospital, Amman Jordan. 6. Medlabs Consultary Group, Amman, Jordan. 7. First Medical Laboratory, Amman, Jordan. 8. Department of Pathology, The University of Jordan, Amman, Jordan. 9. Department of Special Surgery, The University of Jordan, Amman, Jordan. 10. Department of Hematology and Medical Oncology, The University of Jordan, Amman, Jordan. 11. Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan.
Abstract
OBJECTIVE/ BACKGROUND: Lymphoma is a common human cancer that shows a variable geographic incidence worldwide. It is the fourth most common cancer in Jordan. Systemic reports of descriptive epidemiology on lymphoma from the Middle East are limited. METHODS: A nationwide multi-institutional retrospective study was conducted covering all major hospitals and laboratories that provide diagnostic services. We collected data on all cases diagnosed with lymphoma between 2014 and 2019. The included variables were patients' age, gender, anatomic site, and the histologic type according to the World Health Organization classification system. RESULTS: A total of 4189 cases were diagnosed with lymphoma. There was a statistically significant gender difference (p < .05), as 57.5% of patients were males. The peak incidence occurred at age 25-55 years. There were 1,652 (39%) cases of Hodgkin lymphoma (HL) and 2,537 (61%) of non-Hodgkin lymphoma (NHL), where nodular sclerosis (67%) and diffuse large B-cell lymphoma (53%) were the most common subtypes, respectively. The average age-adjusted incidence rates per 100,000 population were 8.01 for all lymphomas, 4.33 for NHL, and 3.16 for HL and all remained stable over the 6 years. CONCLUSION: HL is the most common lymphoma in Jordan, with a percentage higher than most of reported studies in Asian and Western countries. It also shows a unimodal distribution of age-specific incidence rates, with a single peak in young adults. The incidence rate of HL is higher than Eastern countries but comparable to the West. In contrast, NHL demonstrates a lower incidence rate than Western countries but a similar distribution of subtypes, as mature T/natural killer-cell lymphomas were rare.
OBJECTIVE/ BACKGROUND: Lymphoma is a common human cancer that shows a variable geographic incidence worldwide. It is the fourth most common cancer in Jordan. Systemic reports of descriptive epidemiology on lymphoma from the Middle East are limited. METHODS: A nationwide multi-institutional retrospective study was conducted covering all major hospitals and laboratories that provide diagnostic services. We collected data on all cases diagnosed with lymphoma between 2014 and 2019. The included variables were patients' age, gender, anatomic site, and the histologic type according to the World Health Organization classification system. RESULTS: A total of 4189 cases were diagnosed with lymphoma. There was a statistically significant gender difference (p < .05), as 57.5% of patients were males. The peak incidence occurred at age 25-55 years. There were 1,652 (39%) cases of Hodgkin lymphoma (HL) and 2,537 (61%) of non-Hodgkin lymphoma (NHL), where nodular sclerosis (67%) and diffuse large B-cell lymphoma (53%) were the most common subtypes, respectively. The average age-adjusted incidence rates per 100,000 population were 8.01 for all lymphomas, 4.33 for NHL, and 3.16 for HL and all remained stable over the 6 years. CONCLUSION: HL is the most common lymphoma in Jordan, with a percentage higher than most of reported studies in Asian and Western countries. It also shows a unimodal distribution of age-specific incidence rates, with a single peak in young adults. The incidence rate of HL is higher than Eastern countries but comparable to the West. In contrast, NHL demonstrates a lower incidence rate than Western countries but a similar distribution of subtypes, as mature T/natural killer-cell lymphomas were rare.