Arpan R Mehta1,2, Tamás Szakmany3,4, Annie Sorbie5. 1. Centre for Clinical Brain Sciences, Edinburgh bioQuarter, Edinburgh, EH16 4SB, UK. 2. Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK. 3. Critical Care Directorate, Aneurin Bevan University Health Board, 97644Royal Gwent Hospital, Newport, NP20 3UB, UK. 4. Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, CF14 4XN, UK. 5. School of Law, University of Edinburgh, South Bridge, Edinburgh, EH8 9YL, UK.