Literature DB >> 33210492

[Effects of antihyperglycemics on endothelial progenitor cells].

Xue Han1,2, Guojun Jiang2, Qiaojuan Shi1.   

Abstract

Endothelial progenitor cells (EPCs) play an important role in diabetic vascular complications. A large number of studies have revealed that some clinical antihyperglycemics can improve the complications of diabetes by regulating the function of EPCs. Metformin can improve EPCs function in diabetic patients by regulating oxidative stress level or downstream signaling pathway of adenosine monophosphate activated protein kinase; Pioglitazone can delay the aging of EPCs by regulating telomerase activity; acarbose, sitagliptin and insulin can promote the proliferation, migration and adhesion of EPCs. In addition to lowering blood glucose, the effects of antihyperglycemics on EPCs may also be one of the mechanisms to improve the complications of diabetes. This article reviews the research progress on the regulation of EPC proliferation and function by antihyperglycemics.

Entities:  

Keywords:  Antihyperglycemics; Diabetes mellitus; Endothelial progenitor cells; Oxidative stress; Review; Telomerase

Mesh：

Substances：

Year:  2020        PMID： 33210492      PMCID： PMC8800672          DOI： 10.3785/j.issn.1008-9292.2020.10.13

Source DB:  PubMed          Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban        ISSN： 1008-9292


  56 in total

1.  Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions.

Authors:  Suparna Ghosh; Arun P Lakshmanan; Mu Ji Hwang; Haidar Kubba; Ahmed Mushannen; Chris R Triggle; Hong Ding
Journal:  Biochem Pharmacol       Date:  2015-10-20       Impact factor: 5.858

2.  Acute Effects of Linagliptin on Progenitor Cells, Monocyte Phenotypes, and Soluble Mediators in Type 2 Diabetes.

Authors:  Gian Paolo Fadini; Benedetta Maria Bonora; Roberta Cappellari; Lisa Menegazzo; Monica Vedovato; Elisabetta Iori; Maria Cristina Marescotti; Mattia Albiero; Angelo Avogaro
Journal:  J Clin Endocrinol Metab       Date:  2015-12-22       Impact factor: 5.958

3.  Optimized glycaemic control achieved with add-on basal insulin therapy improves indexes of endothelial damage and regeneration in type 2 diabetic patients with macroangiopathy: a randomized crossover trial comparing detemir versus glargine.

Authors:  G P Fadini; S V de Kreutzenberg; V Mariano; E Boscaro; F Bertolini; P Mancuso; J Quarna; M Marescotti; C Agostini; A Tiengo; A Avogaro
Journal:  Diabetes Obes Metab       Date:  2011-08       Impact factor: 6.577

4.  Placental growth factor and B-type natriuretic peptide as independent predictors of risk from a multibiomarker panel in suspected acute coronary syndrome (Acute Risk and Related Outcomes Assessed With Cardiac Biomarkers [ARROW]) study.

Authors:  Ruchira Glaser; W Frank Peacock; Alan H B Wu; Reinhold Muller; Martin Möckel; Fred S Apple
Journal:  Am J Cardiol       Date:  2011-01-19       Impact factor: 2.778

5.  Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus.

Authors:  Kun Shan; Chang Liu; Bai-Hui Liu; Xue Chen; Rui Dong; Xin Liu; Yang-Yang Zhang; Ban Liu; Shu-Jie Zhang; Jia-Jian Wang; Sheng-Hai Zhang; Ji-Hong Wu; Chen Zhao; Biao Yan
Journal:  Circulation       Date:  2017-08-31       Impact factor: 29.690

6.  Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis.

Authors:  Tracey Gaspari; Iressa Spizzo; HongBin Liu; Yunshan Hu; Richard W Simpson; Robert E Widdop; Anthony E Dear
Journal:  Diab Vasc Dis Res       Date:  2017-10-04       Impact factor: 3.291

7.  Inhibitory effect of glyceollins on vasculogenesis through suppression of endothelial progenitor cell function.

Authors:  Jin-Hwa Choi; Minh Phuong Nguyen; Seok-Yun Jung; Sang-Mo Kwon; Jun-Goo Jee; Jong-Sup Bae; Sangkyu Lee; Min Young Lee; You-Mie Lee
Journal:  Mol Nutr Food Res       Date:  2013-06-19       Impact factor: 5.914

8.  Pioglitazone improves in vitro viability and function of endothelial progenitor cells from individuals with impaired glucose tolerance.

Authors:  Valentina Spigoni; Angela Picconi; Monia Cito; Valentina Ridolfi; Sabrina Bonomini; Chiara Casali; Ivana Zavaroni; Luigi Gnudi; Marco Metra; Alessandra Dei Cas
Journal:  PLoS One       Date:  2012-11-05       Impact factor: 3.240

9.  DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study.

Authors:  Kazufumi Nakamura; Hiroki Oe; Hajime Kihara; Kenei Shimada; Shota Fukuda; Kyoko Watanabe; Tsutomu Takagi; Kei Yunoki; Toru Miyoshi; Kumiko Hirata; Junichi Yoshikawa; Hiroshi Ito
Journal:  Cardiovasc Diabetol       Date:  2014-07-30       Impact factor: 9.951

10.  Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study.

Authors:  Dimitrios Oikonomou; Stefan Kopf; Rüdiger von Bauer; Zdenka Djuric; Rita Cebola; Anja Sander; Stefan Englert; Spiros Vittas; Asa Hidmark; Michael Morcos; Grigorios Korosoglou; Peter P Nawroth; Per M Humpert
Journal:  Cardiovasc Diabetol       Date:  2014-10-11       Impact factor: 9.951
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  1 in total

Review 1.  Research progress in endothelial cell injury and repair.

Authors:  Yongpan Huang; Chong Song; Jianbin He; Min Li
Journal:  Front Pharmacol       Date:  2022-09-13       Impact factor: 5.988
  1 in total

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