Multislice spiral computed tomography can independently predict the bronchoscopy results of children with bronchitis (pneumonia) suspected caused by bronchial foreign bodies.

BACKGROUND: Multislice spiral computed tomography (MSCT) playsa vital role in the diagnosis of bronchial foreign bodies in children. Bronchitis (pneumonia) can be caused by bronchial foreign bodies in children, which need to be diagnosed and treated by bronchoscopy. To understand the application of MSCT in children with bronchitis (pneumonia) suspected to be caused by bronchial foreign bodies, the clinical data of 162 children were analyzed retrospectively.
METHODS: The clinical data of 162 children with bronchitis (pneumonia) suspected to be caused by bronchial foreign bodies were collected, including sex, age, course of the disease, auscultation, chest X-ray, MSCT, bronchoscopy, among many others. Univariate logistic regression analysis analyzed the above other items, taking the finding of foreign bodies in bronchoscopy as the outcome index. The key variables of univariate analysis are included in multivariate logistic regression analysis to determine the independent influencing factors of bronchoscopy results.
RESULTS: Among the 162 patients, 70.4% were male, with the largest proportion of children aged 1-2 years (55.6%). The course of the disease of 98 cases (60.4%) was over14 days. A total of 111 cases (68.5%) showed positive auscultation, 110 cases (67.9%) showed positive chest fluoroscopy, 155 cases (95.7%) showed bronchial foreign bodies with MSCT, and the foreign bodies of 140 cases (86.4%) were removed by bronchoscopy. Univariate analysis showed that the course of the disease, chest auscultation, and MSCT were all correlated with the results of bronchoscopy. However, multivariate analysis showed, after adjusting the two factors of chest auscultation and chest fluoroscopy, the course of the disease (OR =6.01, 2.36-15.29, P<0.001) and MSCT (OR =95.64, 5.62-1,628.40, P<0.002) could still independently predict the results of bronchoscopy.
CONCLUSIONS: MSCT can independently predict the results of bronchoscopy in children with bronchitis(pneumonia) suspected to be caused by bronchial foreign bodies. 2020 Translational Pediatrics. All rights reserved.

Introduction

Foreign objects cause children’s bronchial foreign bodies by entering the human bronchial tubes. It is a typical emergency among children and can cause potentially fatal sequelae (1). When the diagnosis is precise, timely bronchoscopy and foreign body removal are the most common treatment methods for children with bronchial foreign bodies (2). However, in daily clinical practice, many bronchial foreign bodies in children have not been diagnosed in time. The delayed diagnosis of bronchial foreign bodies in children is related to pulmonary complications, including pneumonia and bronchiectasis (3). Childhood bronchial pneumonia is the most common disease of the children’s respiratory system, and most of them are community-acquired. When it appears as a complication of a bronchial foreign body, the treatment process is often not straightforward. Because of insufficient cognitive ability and inadequate supervision, the history of inhalation of foreign bodies in children is not straightforward to determine (4). Therefore, when we receive pneumonia caused by a suspected bronchial foreign body, we must promptly assess whether the respiratory tract is unobstructed, and perform a bronchoscopy to remove the foreign body as soon as the diagnosis is precise.

Multislice spiral computed tomography (MSCT) can clearly display the morphology of the bronchus at all levels. Through three-dimensional reconstruction, you can check whether the lumen of the bronchus is unobstructed, and it can predict the results of bronchoscopy very accurately. Studies have shown the sensitivity of MSCT to bronchial foreign bodies can reach 95.5% (4). The virtual bronchoscopy technology with MSCT is the only imaging method that can guarantee 99.9% of foreign bodies (5). To improve the safety of surgical procedures, Ozdemir recommends that rigid bronchoscopy for pediatric patients with bronchial foreign bodies should be assisted by an endoscope to allow more effective visualization of the distal bronchus and foreign bodies (6). Carlens retrospectively analyzed the data of bronchoscopy in 522 children aged from 0 to 17 years old. It was found that hypoxemia was the most common intraoperative complication, and fever and transient oxygen dependence were the most common postoperative complications (7). To understand the application of MSCT in children with bronchitis (pneumonia) suspected to be caused by foreign bodies in the bronchial, we retrospectively analyzed the clinical data of 162 related children. We present the following article in accordance with the STROBE reporting checklist (available at http://dx.doi.org/10.21037/tp-20-300).

Methods

Patients

One hundred sixty-two patients with bronchitis(pneumonia) suspected of being caused by foreign bodies in the bronchial were selected as the object of study. All subjects were diagnosed with bronchitis (pneumonia) by symptoms, auscultation and plain chest X-ray examination, the nursing family members could not provide a clear history of foreign body inhalation, and the vital signs of the children were stable, and meet one of the following inclusion criteria: (I) severe atelectasis and emphysema at the time of diagnosis; (II) symptoms and imaging recovery are not apparent after a week of routine treatment; (III) repeated attacks after improvement of bronchitis(pneumonia) in the same position. Patients who met one of the following conditions will be excluded from this study: (I) with immunodeficiency disease; (II) with bronchopulmonary malformation; (III) caregiver family members provide a clear history of foreign body inhalation.

The study was approved by the Ethics Committee of Tianjin Children’s Hospital (No. L2020-31) and written informed consent was obtained from all patients. All procedures performed in this study involving human participants were in accordance with the Declaration of Helsinki (as revised in 2013).

Treatments

After medical history collection and physical examination, all hospitalized patients with bronchitis (pneumonia) were routinely treated with the empirical anti-infective treatment of antibiotics, expectorant treatment, aerosol inhalation, and other symptomatic support treatment. Patients with bronchitis (pneumonia) following the above characteristics were examined by chest fluoroscopy and MSCT to test whether bronchitis (pneumonia) was secondary to foreign bodies in the bronchial. After a precise diagnosis, bronchoscopy was performed. Chest auscultation found that unilateral respiratory sounds decreased and wheezing was positive; Chest fluoroscopy found that mediastinal contradictory movement was positive; MSCT found local obstruction or bronchial stenosis was positive; bronchoscopy found that exogenous foreign bodies were positive.

MSCT

The 16 slice spiral CT (Siemens, Germany) was used for scanning. Cooperative children were instructed to hold their breath for 5s-7s, and uncooperative children were sedated with 10% chloral hydrate to calm their breathing. A thin layer volume scan was performed from the beginning of the trachea to the top of the right diaphragm, and a 0.75 mm thickness detector was used to collect data. After scanning, 20 mm slice thickness and 0.05 mm slice spacing were selected for later reconstruction. The SYNGO system was used for post-image processing, mainly using multi-planar reformation (MPR), curve multi-planar reformation (CMPR), minimum intensity projective (MinIP), volume rendering technique (VRT), CT virtual endoscopy (CTVE), shaded surface display (SSD) and other reconstruction methods.

Bronchoscopy

The rigid bronchoscope produced by the Storz company in Germany was used for examination (fiberoptic bronchoscope and endoscope were used together). After general anesthesia, the corresponding bronchoscope was placed through the mouth, and the glottis, trachea, carina, bilateral bronchus, lobar bronchus and the orifice of each segmental bronchus were examined sequentially. In principle, first, check the healthy side, and then check the affected side, focus on the suspicious part of the observation. If a foreign body is found, then try to remove it.

Statistical method

Sex, chest auscultation, chest fluoroscopy, MSCT, and bronchoscopy were the classified variables, while age and course of disease were continuous variables. Taking whether bronchoscopy found the foreign bodies as the outcome index, univariate logistic regression analysis analyzed the other items, and the critical variables of univariate analysis were included in multivariate logistic regression analysis.

Results

Patient clinical characteristics

As shown in , 70.4% of the 162patients were male; children aged 1–2 years accounted for the most substantial proportion, accounting for 55.6%; Most of the children (60.4%) whose course of the disease was over 14 days; 111 cases (68.5%) had positive chest auscultation, 110 cases (67.9%) showed positive chest fluoroscopy, 155 cases (95.7%) showed bronchial foreign bodies with MSCT, and the foreign bodies of 140 cases (86.4%) were removed by bronchoscopy.

Table1

Patient clinical characteristics

Characteristics	Total n, (%)
Total	162 (100.0)
Sex
Male	114 (70.4)
Female	48 (29.6)
Age, years old
≤1	8 (4.9)
1–2	90 (55.6)
2–3	39 (24.1)
≥3	25 (15.4)
The course of the disease, days
≤7	9 (5.6)
7–14	55 (34.0)
≥14	98 (60.4)
Chest auscultation
Negative	51 (31.5)
Positive	111 (68.5)
Chest fluoroscopy
Negative	52 (32.1)
Positive	110 (67.9)
MSCT
Negative	7 (4.3)
Positive	155 (95.7)
Bronchoscopy
Negative	22 (13.6)
Positive	140 (86.4)

MSCT, multislice spiral computed tomography.

Results of bronchoscopy

As shown in , among the 162 patients, foreign bodies were located in left bronchi in 69 cases, right bronchi in 62 cases, bilateral bronchi in 9 cases, no exogenous foreign bodies in 22 cases; There were vegetative foreign bodies in 107 cases, chemical foreign bodies in 15 cases, animal foreign bodies in 12 cases and mineral foreign bodies in 6 cases. shows the foreign body removed by rigid bronchoscope.

Table 2

Results of bronchoscopy in 162 children

Variable	Total n, (%)
Location of foreign bodies
Total	162 (100.0)
Left bronchus	69 (42.6)
Right bronchus	62 (38.3)
Bilateral bronchus	9 (5.6)
No foreign body	22 (13.5)
Type of foreign bodies
Total	140 (100.0)
Vegetative foreign bodies	107 (76.4)
Chemical foreign bodies	15 (10.7)
Animal foreign bodies	12 (8.6)
Mineral foreign bodies	6 (4.3)

Figure 1

The foreign body removed by rigid bronchoscope.

Results of MSCT

As shown in , MSCT showed a partial obstruction in 124 cases, bronchial stenosis in 31 cases, no signs of foreign bodies in 7 cases, MSCT found complications: emphysema in 95 cases, atelectasis in 68 cases, mediastinal shift in 65 cases, pleural effusion in 16 cases. shows that CTVE can clearly show the foreign body and its incarcerated site.

Table 3

Results of MSCT in 162 children

Variable	Total n, (%)
MSCT
Total	162 (100.0)
Partial obstruction	124 (76.5)
Bronchial stenosis	31 (19.2)
No sign of a foreign bodies	7 (4.3)
Complications
Total	162 (100.0)
Emphysema	95 (58.6)
Atelectasis	68 (42.0)
Mediastinal shift	65 (40.1)
Pleural effusion	16 (9.9)

MSCT, multislice spiral computed tomography.

Figure 2

CTVE clearly shows the foreign body and its incarcerated site. CTVE, CT virtual endoscope.

Univariate and multivariate logistic regression analysis

As shown in , univariate analysis showed that the course of the disease, auscultation, and MSCT were all correlated with the results of bronchoscopy, while multivariate analysis showed after adjusting the two factors of auscultation and chest X-ray, the course of the disease (OR =6.01, 2.36–15.29, P<0.001) and MSCT (OR =95.64, 5.62–1,628.40, P<0.002) could still independently predict the results of bronchoscopy.

Table 4

Univariate and multivariate logistic regression analysis for predicting bronchoscopy results

Variables	Univariate				Multivariate
	OR	95% CI	P value		OR	95% CI	P value
Sex	1.51	0.52–4.35	0.448
Age	1.09	0.62–1.90	0.777
The course of the disease	5.73	2.60–12.64	<0.001		6.01	2.36–15.29	<0.001
Auscultation	3.11	1.24–7.78	0.015		3.63	0.99–13.20	0.051
Chest fluoroscopy	0.60	0.21–1.73	0.345		0.20	0.04–1.16	0.074
MSCT	52.13	5.90–460.80	<0.001		95.64	5.62–1,628.40	0.002

MSCT, multislice spiral computed tomography.

Discussion

A bronchial foreign body is the most common emergency in otorhinolaryngology in children. The diagnosis depends on the history of foreign body inhalation, pulmonary auscultation, and chest fluoroscopy. In the cases with a short course of disease, clear history of foreign body inhalation, lung auscultation to the asymmetry of breathing sound on both sides (one side reduced), and typical mediastinal swing can be identified by chest fluoroscopy, and it is easy to diagnose. Timely bronchoscopy and removal of a foreign body can save the child from danger. However, in clinical work, family members cannot provide or explicitly deny the history of foreign body inhalation, and patients with bronchial foreign bodies with pneumonia as the first manifestation will be delayed in diagnosis and treatment, which poses a severe threat to the physical health of children and the psychological status of their families.

Bronchoscopy is the gold standard for the diagnosis of bronchial foreign bodies in children, but the negative rate of bronchoscopy is very high, which brings unnecessary risks and costs of surgery and anesthesia to patients. MSCT has high sensitivity and specificity for bronchial foreign bodies. Selective application of MSCT in the clinical nursing program of children with suspected foreign body inhalation can significantly reduce the negative rate of bronchoscopy, thus reducing the operational risk and cost (8).

Although many studies have confirmed MSCT can accurately diagnose bronchial foreign bodies (9-12). However, because it belongs to the radiological examination, it cannot be routinely and widely used in this particular group of pediatrics. We usually use MSCT in the diagnosis of bronchial foreign bodies only when the routine diagnostic indicators are atypical. Therefore, we selected 162 patients with bronchitis (pneumonia) suspected of being caused by foreign bodies in the bronchial, and underwent MSCT and bronchoscopy. We found that bronchial foreign bodies were common in bronchitis (pneumonia) patients whose care family members could not accurately provide a history of foreign body inhalation, and routine diagnostic indicators of tracheal foreign bodies could not give satisfactory diagnostic results in the course of the disease. However, MSCT could independently predict the results of bronchoscopy.

Hajnal’s study, showed that the positive rate of chest auscultation in patients with bronchial foreign bodies with a clear history of foreign body inhalation was 89.5%, while chest fluoroscopy was only 21.1%. And 33.7% of the patients showed negative results of bronchoscopy. The complication rate of patients with a prolonged course of the disease was significantly higher than acute cases. Therefore, they concluded that rigid bronchoscopy could be performed as long as the history of foreign body inhalation is clear, the symptoms (cough, asphyxia) are typical, or the chest auscultation is positive (13). We also found there was a significant correlation between chest auscultation and a bronchoscopy in univariate analysis (P=0.015), which was like the above results. Our study selected children with suspected bronchial foreign bodies who could not supply a history of foreign body inhalation, so the other data were inconsistent. Our study precisely makes up for the deficiency of this study. In patients with an uncertain history of foreign body inhalation, MSCT can predict the results of bronchoscopy and improve the positive rate of bronchoscopy. Our study also suggests we should pay attention to the importance of physical examination (chest auscultation) in clinical work.

Our study also has the following limitations. One, this study, is a retrospective study, and some selection biases are inevitable. Two, this study is a single-center study with a small sample size. Three, our study included fewer indicators. Therefore, in the following clinical work, we must further increase the evaluation indicators, expand the sample size, and conduct multi-center and prospective studies to achieve more reliable research conclusions.

Conclusions

According to our results, MSCT can independently predict the results of bronchoscopy in children with bronchitis (pneumonia) suspected to be caused by bronchial foreign bodies. Bronchitis (pneumonia) with a long history, especially those with inadequate response to routine treatment, should be examined by MSCT in time, and bronchoscopy and treatment should be performed as soon as possible after definite diagnosis.

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