Jin Xu1, Meng Zhang1, Gang Cheng2. 1. Department of Medical Ultrasonics, the Affiliated Hospital of Jiangnan University, Wuxi, China. 2. Department of Medical Ultrasonics, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Abstract
BACKGROUND: Contrast-enhanced ultrasonography (CE-US) brings a higher signal-to-noise ratio and a higher sensitivity for slow flow than traditional B-mode ultrasonography (US). However, it remains unclear whether CE-US is also superior to B-mode US in detecting early-stage pancreatic cancer (PC). METHODS: This was a retrospective study enrolling patients suspected of pancreatic insufficiency between June 2015 and December 2019. Enrolled patients successively received B-mode US and CE-US examinations, and some their demographic and clinical data were collected. The diagnostic capacity of the two examinations was calculated and receiver operating characteristic (ROC) curves was used to compare the area under the curve (AUC). A subgroup analysis was performed to explore the effects of tumor size on the diagnostic accuracy of B-mode US and CE-US. RESULTS: There were 128 patients enrolled in this study; 74 patients were diagnosed as early-stage PC patients and the remaining 54 were diagnosed with benign pancreatic lesions. The mean size of the PC was 17.8±4.9 mm. The results revealed that 68 of the 74 PC patients were correctly diagnosed by CE-US, and all 54 patients with benign pancreatic lesions were also correctly diagnosed. Meanwhile, only 55 of the 74 PC patients and 50 of the 54 patients with benign pancreatic lesions were diagnosed correctly using B-mode US. The ROC curve showed that the AUCs of CE-US and B-mode US were 0.959 and 0.835, respectively. According to the subgroup analysis, CE-US exhibited better accuracy than B-mode US for smaller tumors (size <20 mm, P=0.002; size <10 mm, P=0.043; size <5 mm, P=0.025). CONCLUSIONS: CE-US was clearly superior to the conventional B-mode US in detecting early-stage PC, especially smaller sized PC. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
BACKGROUND: Contrast-enhanced ultrasonography (CE-US) brings a higher signal-to-noise ratio and a higher sensitivity for slow flow than traditional B-mode ultrasonography (US). However, it remains unclear whether CE-US is also superior to B-mode US in detecting early-stage pancreatic cancer (PC). METHODS: This was a retrospective study enrolling patients suspected of pancreatic insufficiency between June 2015 and December 2019. Enrolled patients successively received B-mode US and CE-US examinations, and some their demographic and clinical data were collected. The diagnostic capacity of the two examinations was calculated and receiver operating characteristic (ROC) curves was used to compare the area under the curve (AUC). A subgroup analysis was performed to explore the effects of tumor size on the diagnostic accuracy of B-mode US and CE-US. RESULTS: There were 128 patients enrolled in this study; 74 patients were diagnosed as early-stage PC patients and the remaining 54 were diagnosed with benign pancreatic lesions. The mean size of the PC was 17.8±4.9 mm. The results revealed that 68 of the 74 PC patients were correctly diagnosed by CE-US, and all 54 patients with benign pancreatic lesions were also correctly diagnosed. Meanwhile, only 55 of the 74 PC patients and 50 of the 54 patients with benign pancreatic lesions were diagnosed correctly using B-mode US. The ROC curve showed that the AUCs of CE-US and B-mode US were 0.959 and 0.835, respectively. According to the subgroup analysis, CE-US exhibited better accuracy than B-mode US for smaller tumors (size <20 mm, P=0.002; size <10 mm, P=0.043; size <5 mm, P=0.025). CONCLUSIONS: CE-US was clearly superior to the conventional B-mode US in detecting early-stage PC, especially smaller sized PC. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
Authors: M D'Onofrio; S Crosara; M Signorini; R De Robertis; S Canestrini; F Principe; R Pozzi Mucelli Journal: Ultraschall Med Date: 2012-09-21 Impact factor: 6.548
Authors: Marcel H A Muskiet; Anna L Emanuel; Mark M Smits; Lennart Tonneijck; Rick I Meijer; Jaap A Joles; Erik H Serné; Daniël H van Raalte Journal: Microcirculation Date: 2019-08-26 Impact factor: 2.628