Veronique Demers-Mathieu1, Gabrielle B Mathijssen2, Ciera DaPra2, Elena Medo2. 1. Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA. vdemers-m@medolac.com. 2. Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.
Abstract
OBJECTIVE: This study investigated the impact of probiotic supplementation on the gene expressions of cluster of differentiation (CD) as cell markers and the concentrations of antibodies and cytokines in human milk. STUDY DESIGN: Gene expressions of CD28, CD19, and CD38 were determined in milk from 15 women ingesting daily probiotics (from Greek yogurt) and 12 women who do not consume probiotics. Concentrations of antibodies and cytokines were measured using ELISA. RESULTS: Gene expression of CD28 tended to be higher in milk from mothers ingesting daily probiotics than mothers who did not take probiotics. Interleukin-6 (IL-6) concentration in milk was higher in mothers ingesting probiotics than those who do not consume probiotics. The increase of IL-6 level in human milk was positively correlated with total IgA and IgG concentrations. CONCLUSIONS: Probiotic supplementation could enhance the secretion of IL-6 in human milk. Human milk IL-6 may improve neonatal immunity due to its stimulation of total IgA and IgG.
OBJECTIVE: This study investigated the impact of probiotic supplementation on the gene expressions of cluster of differentiation (CD) as cell markers and the concentrations of antibodies and cytokines in human milk. STUDY DESIGN: Gene expressions of CD28, CD19, and CD38 were determined in milk from 15 women ingesting daily probiotics (from Greek yogurt) and 12 women who do not consume probiotics. Concentrations of antibodies and cytokines were measured using ELISA. RESULTS: Gene expression of CD28 tended to be higher in milk from mothers ingesting daily probiotics than mothers who did not take probiotics. Interleukin-6 (IL-6) concentration in milk was higher in mothers ingesting probiotics than those who do not consume probiotics. The increase of IL-6 level in human milk was positively correlated with total IgA and IgG concentrations. CONCLUSIONS: Probiotic supplementation could enhance the secretion of IL-6 in human milk. Human milk IL-6 may improve neonatal immunity due to its stimulation of total IgA and IgG.
Authors: Michel Jourdan; Anouk Caraux; Gersende Caron; Nicolas Robert; Geneviève Fiol; Thierry Rème; Karine Bolloré; Jean-Pierre Vendrell; Simon Le Gallou; Frédéric Mourcin; John De Vos; Alboukadel Kassambara; Christophe Duperray; Dirk Hose; Thierry Fest; Karin Tarte; Bernard Klein Journal: J Immunol Date: 2011-09-14 Impact factor: 5.422
Authors: Edouard Tuaillon; Diane Valea; Pierre Becquart; Yassine Al Tabaa; Nicolas Meda; Karine Bollore; Philippe Van de Perre; Jean-Pierre Vendrell Journal: J Immunol Date: 2009-06-01 Impact factor: 5.422
Authors: Veronique Demers-Mathieu; Ciera DaPra; Gabrielle Mathijssen; David A Sela; Kirsi M Jarvinen; Antti Seppo; Shawn Fels; Elena Medo Journal: Int J Mol Sci Date: 2021-02-09 Impact factor: 5.923