Karen E Skinner1, Amin Haiderali2, Min Huang2, Lee S Schwartzberg3. 1. Vector Oncology, an affiliate of ConcertAI, 6555 Quince, Suite 400, Memphis, TN 38119, USA. 2. Merck & Co., Inc., 351 N. Sumneytown Pike, North Wales, PA 19454, USA. 3. West Cancer Center, 7945 Wolf River Boulevard, Germantown, TN 38138, USA.
Abstract
Aim: This study examined treatment patterns and effectiveness outcomes of patients with metastatic triple-negative breast cancer (mTNBC) from US community oncology centers. Materials & methods: Eligible patients were females, aged ≥18 years, diagnosed with mTNBC between 1 January 2010 and 31 January 2016. Kaplan-Meier and Cox regression methods were used. Results: Sample comprised 608 patients with average age of 57.5 years and 505/608 patients (83.1%) received systemic treatment. Overall survival (OS) from first-line treatment found that African-American patients had shorter OS than White (9.3 vs 13.7 months; hazard ratio: 1.35; p = 0.006). Conclusion: More than 15% of women with mTNBC were not treated, indicating a high unmet need. Overall prognosis remains poor, which highlights the opportunity for newer therapies to improve progression-free survival and OS.
Aim: This study examined treatment patterns and effectiveness outcomes of patients with metastatic triple-negative breast cancer (mTNBC) from US community oncology centers. Materials & methods: Eligible patients were females, aged ≥18 years, diagnosed with mTNBC between 1 January 2010 and 31 January 2016. Kaplan-Meier and Cox regression methods were used. Results: Sample comprised 608 patients with average age of 57.5 years and 505/608 patients (83.1%) received systemic treatment. Overall survival (OS) from first-line treatment found that African-American patients had shorter OS than White (9.3 vs 13.7 months; hazard ratio: 1.35; p = 0.006). Conclusion: More than 15% of women with mTNBC were not treated, indicating a high unmet need. Overall prognosis remains poor, which highlights the opportunity for newer therapies to improve progression-free survival and OS.
Entities:
Keywords:
African–American patients; community oncology; metastatic triple-negative breast cancer; overall survival; progression-free survival; treatment patterns
Authors: Nicholas R Hum; Aimy Sebastian; Kelly A Martin; Naiomy D Rios-Arce; Sean F Gilmore; David M Gravano; Elizabeth K Wheeler; Matthew A Coleman; Gabriela G Loots Journal: Front Oncol Date: 2022-07-18 Impact factor: 5.738