| Literature DB >> 33206973 |
Anne-Sophie Bedin1, Alain Makinson2,3, Marie-Christine Picot4,5, Frank Mennechet1, Fabrice Malergue6, Amandine Pisoni1,7, Esperance Nyiramigisha7, Lise Montagnier7, Karine Bollore1, Ségolène Debiesse1, David Morquin3, Nicolas Veyrenche7, Constance Renault1, Vincent Foulongne1,7, Caroline Bret8, Arnaud Bourdin9,10, Vincent Le Moing2,3, Philippe Van de Perre1,7, Edouard Tuaillon1,7.
Abstract
We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.Entities:
Keywords: CD169; COVID-19; SARS-CoV-2; monocytes; viral infections
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Year: 2021 PMID： 33206973 PMCID： PMC7717347 DOI： 10.1093/infdis/jiaa724
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226