| Literature DB >> 33206346 |
Liang Zhang1, Dengchang Li1, Shenglan Yu2.
Abstract
Harmine is isolated from the seeds of the medicinal plant, Peganum harmala L., and has been used for thousands of years in the Middle East and China. Harmine has many pharmacological activities including anti-inflammatory, neuroprotective, antidiabetic, and antitumor activities. Moreover, harmine exhibits insecticidal, antiviral, and antibacterial effects. Harmine derivatives exhibit pharmacological effects similar to those of harmine, but with better antitumor activity and low neurotoxicity. Many studies have been conducted on the pharmacological activities of harmine and harmine derivatives. This article reviews the pharmacological effects and associated mechanisms of harmine. In addition, the structure-activity relationship of harmine derivatives has been summarized.Entities:
Keywords: Anti-tumor; Antidiabetic; Derivatives; Harmine; Neuroprotective effects; Pharmacological effects
Mesh：
Substances：
Year: 2020 PMID： 33206346 DOI： 10.1007/s12272-020-01283-6
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946