Shengzhi Sun1,2, Wangnan Cao3, Yang Ge4, Jinjun Ran2, Feng Sun5, Qiang Zeng6, Mengdi Guo7, Jianxiang Huang7, Ruby Siu-Yin Lee8, Linwei Tian2, Gregory A Wellenius1. 1. Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA. 2. School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region. 3. Center for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI 02912, USA. 4. School of Public Health, Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA 30606, USA. 5. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China. 6. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. 7. Department of Urban Planning and Design, The University of Hong Kong, Hong Kong Special Administrative Region. 8. Elderly Health Service, Department of Health, Hong Kong Special Administrative Region.
Abstract
AIMS: We estimated the association between outdoor light at night at the residence and risk of coronary heart disease (CHD) within a prospective cohort of older adults in Hong Kong. METHODS AND RESULTS: Over a median of 11 years of follow-up, we identified 3772 incident CHD hospitalizations and 1695 CHD deaths. Annual levels of outdoor light at night at participants' residential addresses were estimated using time-varying satellite data for a composite of persistent night-time illumination at ∼1 km2 scale. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between outdoor light at night at the residence and risk of CHD. The association between light at night and incident CHD hospitalization and mortality exhibited a monotonic exposure-response function. An interquartile range (IQR) (60.0 nW/cm2/sr) increase in outdoor light at night was associated with an HR of 1.11 (95% CI: 1.03, 1.18) for CHD hospitalizations and 1.10 (95% CI: 1.00, 1.22) for CHD deaths after adjusting for both individual and area-level risk factors. The association did not vary across strata of hypothesized risk factors. CONCLUSION: Among older adults, outdoor light at night at the residence was associated with a higher risk of CHD hospitalizations and deaths. We caution against causal interpretation of these novel findings. Future studies with more detailed information on exposure, individual adaptive behaviours, and potential mediators are warranted to further examine the relationship between light at night and CHD risk. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: We estimated the association between outdoor light at night at the residence and risk of coronary heart disease (CHD) within a prospective cohort of older adults in Hong Kong. METHODS AND RESULTS: Over a median of 11 years of follow-up, we identified 3772 incident CHD hospitalizations and 1695 CHD deaths. Annual levels of outdoor light at night at participants' residential addresses were estimated using time-varying satellite data for a composite of persistent night-time illumination at ∼1 km2 scale. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between outdoor light at night at the residence and risk of CHD. The association between light at night and incident CHD hospitalization and mortality exhibited a monotonic exposure-response function. An interquartile range (IQR) (60.0 nW/cm2/sr) increase in outdoor light at night was associated with an HR of 1.11 (95% CI: 1.03, 1.18) for CHD hospitalizations and 1.10 (95% CI: 1.00, 1.22) for CHD deaths after adjusting for both individual and area-level risk factors. The association did not vary across strata of hypothesized risk factors. CONCLUSION: Among older adults, outdoor light at night at the residence was associated with a higher risk of CHD hospitalizations and deaths. We caution against causal interpretation of these novel findings. Future studies with more detailed information on exposure, individual adaptive behaviours, and potential mediators are warranted to further examine the relationship between light at night and CHD risk. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Jennifer D'Souza; Jennifer Weuve; Robert D Brook; Denis A Evans; Joel D Kaufman; Sara D Adar Journal: Hypertension Date: 2021-10-25 Impact factor: 10.190
Authors: Naima Covassin; Jan Bukartyk; Prachi Singh; Andrew D Calvin; Erik K St Louis; Virend K Somers Journal: Hypertension Date: 2021-07-12 Impact factor: 9.897