Tomoko Sawada1, Tsutomu Yasukawa2, Hiroko Imaizumi3, Hisashi Matsubara4, Kazuhiro Kimura5, Hiroto Terasaki6, Hiroto Ishikawa7, Tomoya Murakami8, Masaru Takeuchi9, Yoshinori Mitamura10, Mariko Yamashita11, Yoshihiro Takamura12, Toshinori Murata13, Jiro Kogo14, Masahito Ohji15. 1. Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. tsawada@belle.shiga-med.ac.jp. 2. Department of Ophthalmology, Nagoya City University, Nagoya, Japan. 3. Department of Ophthalmology, Sapporo City General Hospital, Sapporo, Japan. 4. Department of Ophthalmology, Mie University, Tsu, Japan. 5. Department of Ophthalmology, Yamaguchi University, Ube, Japan. 6. Department of Ophthalmology, Kagoshima University, Kagoshima, Japan. 7. Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan. 8. Department of Ophthalmology, University of Tsukuba, Tsukuba, Japan. 9. Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan. 10. Department of Ophthalmology, Tokushima University, Tokushima, Japan. 11. Department of Ophthalmology, Nara Medical University, Kashihara, Japan. 12. Department of Ophthalmology, University of Fukui, Yoshida-gun, Japan. 13. Department of Ophthalmology, Shinshu University, Matsumoto, Japan. 14. Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan. 15. Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
Abstract
PURPOSE: We investigated 10-year changes in baseline best-corrected visual acuity (BCVA), as well as functional and anatomical changes at 1 and 2 years after initial treatment, in eyes with treatment-naïve neovascular age-related macular degeneration (nAMD). METHODS: This retrospective, multicenter, case series reviewed patients with treatment-naïve nAMD who underwent initial treatment from 2006 to 2015, using photodynamic therapy (PDT), anti-vascular endothelial growth factor (VEGF), or a combination of PDT and anti-VEGF. BCVA and central retinal subfield thickness (CRST), were measured at baseline and at 1 or 2 years of follow-up. RESULTS: In total, 3096 eyes of 3096 patients were included from 14 hospitals. Mean BCVA at baseline became significantly better over the 10-year study period (P < 0.001). BCVA at 1 year significantly improved from baseline in patients who underwent initial treatment from 2009 to 2015 (P = 0.001, 2009; P = 0.004, 2010; P = 0.01, 2011; P < 0.001, 2012-2015). BCVA at 2 years significantly improved from baseline in patients who underwent initial treatment from 2012 to 2015 (P < 0.001, 2012; P < 0.001, 2013-2015). CRST at 1 year decreased significantly from CRST at baseline, each year from 2006 to 2015 (P < 0.001, 2006-2015). CRST at 2 years decreased significantly from CRST at baseline, each year from 2006 to 2015 (P = 0.03, 2006; P < 0.001, 2007-2015). CONCLUSION: Baseline BCVA with treatment-naïve nAMD tended to become better during the study period. BCVA at 1 year improved in the era of anti-VEGF; BCVA at 2 years improved in patients who underwent initial treatment in 2012 or later; and CRST decreased in each year during the study period.
PURPOSE: We investigated 10-year changes in baseline best-corrected visual acuity (BCVA), as well as functional and anatomical changes at 1 and 2 years after initial treatment, in eyes with treatment-naïve neovascular age-related macular degeneration (nAMD). METHODS: This retrospective, multicenter, case series reviewed patients with treatment-naïve nAMD who underwent initial treatment from 2006 to 2015, using photodynamic therapy (PDT), anti-vascular endothelial growth factor (VEGF), or a combination of PDT and anti-VEGF. BCVA and central retinal subfield thickness (CRST), were measured at baseline and at 1 or 2 years of follow-up. RESULTS: In total, 3096 eyes of 3096 patients were included from 14 hospitals. Mean BCVA at baseline became significantly better over the 10-year study period (P < 0.001). BCVA at 1 year significantly improved from baseline in patients who underwent initial treatment from 2009 to 2015 (P = 0.001, 2009; P = 0.004, 2010; P = 0.01, 2011; P < 0.001, 2012-2015). BCVA at 2 years significantly improved from baseline in patients who underwent initial treatment from 2012 to 2015 (P < 0.001, 2012; P < 0.001, 2013-2015). CRST at 1 year decreased significantly from CRST at baseline, each year from 2006 to 2015 (P < 0.001, 2006-2015). CRST at 2 years decreased significantly from CRST at baseline, each year from 2006 to 2015 (P = 0.03, 2006; P < 0.001, 2007-2015). CONCLUSION: Baseline BCVA with treatment-naïve nAMD tended to become better during the study period. BCVA at 1 year improved in the era of anti-VEGF; BCVA at 2 years improved in patients who underwent initial treatment in 2012 or later; and CRST decreased in each year during the study period.
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