| Literature DB >> 33201342 |
Zhouoxing Wei1, Kenta Shimizu2,3, Kumpei Nishigami2, Yoshimi Tsuda2,3, Yomani Sarathukumara4, Devinda S Muthusinghe1, Chandika D Gamage4, Lishanta Granathne5, Sithumini M W Lokupathirage1, Nishanta Nanayakkara6, Jiro Arikawa2,3, Fuka Kikuchi7,8, Keiko Tanaka-Taya7, Motoi Suzuki7, Shigeru Morikawa7, Satoru Arai7, Kumiko Yoshimatsu9,10,11.
Abstract
The infectivity of shrew-borne hantaviruses to humans is still unclear because of the lack of a serodiagnosis method for these viruses. In this study, we prepared recombinant nucleocapsid (rN) proteins of Seewis orthohantavirus, Altai orthohantavirus (ALTV), Thottapalayam thottimvirus (TPMV), and Asama orthohantavirus. Using monospecific rabbit sera, no antigenic cross-reactivity was observed. In a serosurvey of 104 samples from renal patients and 271 samples from heathy controls from Sri Lanka, one patient serum and two healthy control sera reacted with rN proteins of ALTV and TPMV, respectively. The novel assays should be applied to investigate potential infectivity of shrew-borne hantaviruses to humans.Entities:
Year: 2020 PMID： 33201342 DOI： 10.1007/s00705-020-04873-3
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574