Literature DB >> 33199390

Characterization of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Patients in China.

Ruowen He1,2, Yongqiang Yang1,2,3, Yiping Wu1,2, Lan-Lan Zhong1,2, Min Dai4, Hongtao Chen5, Guo-Bao Tian6,2,7, Yanxian Yang1,2, Guanping Chen8, Mingyang Qin9, Xiaoxue Liang10, Mohamed Abd El-Gawad El-Sayed Ahmed1,2,11, Minmin Lin12, Bin Yan13, Yong Xia14.   

Abstract

Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR Klebsiella quasipneumoniae isolate from a patient with bloodstream infection were identified to carry tmexCD1-toprJ1 The addition of the efflux pump inhibitor reduced the tigecycline MIC against all three isolates by 8- to 16-fold. pKQBSI104-1 was transferred from K. quasipneumoniae to Escherichia coli J53 via conjugation. The tmexCD1-toprJ1-carrying plasmids pKP15ZE495-1 (102,569 bp) and pKQBSI104-1 (121,996 bp) were completely sequenced and analyzed.
Copyright © 2021 American Society for Microbiology.

Entities:  

Keywords:  Klebsiella spp.; antimicrobial resistance; efflux pump; tigecycline; tmexCD1-toprJ1

Mesh：

Substances：

Year:  2021        PMID： 33199390      PMCID： PMC7849012          DOI： 10.1128/AAC.02075-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.

Authors:  Anton Bankevich; Sergey Nurk; Dmitry Antipov; Alexey A Gurevich; Mikhail Dvorkin; Alexander S Kulikov; Valery M Lesin; Sergey I Nikolenko; Son Pham; Andrey D Prjibelski; Alexey V Pyshkin; Alexander V Sirotkin; Nikolay Vyahhi; Glenn Tesler; Max A Alekseyev; Pavel A Pevzner
Journal:  J Comput Biol       Date:  2012-04-16       Impact factor: 1.479

2.  Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health.

Authors:  Kathryn E Holt; Heiman Wertheim; Ruth N Zadoks; Stephen Baker; Chris A Whitehouse; David Dance; Adam Jenney; Thomas R Connor; Li Yang Hsu; Juliëtte Severin; Sylvain Brisse; Hanwei Cao; Jonathan Wilksch; Claire Gorrie; Mark B Schultz; David J Edwards; Kinh Van Nguyen; Trung Vu Nguyen; Trinh Tuyet Dao; Martijn Mensink; Vien Le Minh; Nguyen Thi Khanh Nhu; Constance Schultsz; Kuntaman Kuntaman; Paul N Newton; Catrin E Moore; Richard A Strugnell; Nicholas R Thomson
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-22       Impact factor: 11.205

Review 3.  The emergence of clinical resistance to tigecycline.

Authors:  Yan Sun; Yun Cai; Xu Liu; Nan Bai; Beibei Liang; Rui Wang
Journal:  Int J Antimicrob Agents       Date:  2012-11-03       Impact factor: 5.283

4.  Molecular characterization of extended-spectrum cephalosporinase-producing Salmonella enterica serovar Choleraesuis isolates from patients in Thailand and Denmark.

Authors:  Pantip Sirichote; Henrik Hasman; Chaiwat Pulsrikarn; Henrik Carl Schønheyder; Jurgita Samulioniené; Srirat Pornruangmong; Aroon Bangtrakulnonth; Frank M Aarestrup; Rene S Hendriksen
Journal:  J Clin Microbiol       Date:  2009-12-23       Impact factor: 5.948

5.  Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans.

Authors:  Tao He; Ran Wang; Dejun Liu; Timothy R Walsh; Rong Zhang; Yuan Lv; Yuebin Ke; Quanjiang Ji; Ruicheng Wei; Zhihai Liu; Yingbo Shen; Gang Wang; Lichang Sun; Lei Lei; Ziquan Lv; Yun Li; Maoda Pang; Liyuan Wang; Qiaoling Sun; Yulin Fu; Huangwei Song; Yuxin Hao; Zhangqi Shen; Shaolin Wang; Gongxiang Chen; Congming Wu; Jianzhong Shen; Yang Wang
Journal:  Nat Microbiol       Date:  2019-05-27       Impact factor: 17.745

6.  Identification of acquired antimicrobial resistance genes.

Authors:  Ea Zankari; Henrik Hasman; Salvatore Cosentino; Martin Vestergaard; Simon Rasmussen; Ole Lund; Frank M Aarestrup; Mette Voldby Larsen
Journal:  J Antimicrob Chemother       Date:  2012-07-10       Impact factor: 5.790

7.  Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity.

Authors:  Won-Hee Lee; Hyun-Il Choi; Sung-Wook Hong; Kwang-Sun Kim; Yong Song Gho; Seong Gyu Jeon
Journal:  Exp Mol Med       Date:  2015-09-11       Impact factor: 8.718

8.  Whole-Genome Sequencing of Human Clinical Klebsiella pneumoniae Isolates Reveals Misidentification and Misunderstandings of Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae.

Authors:  S Wesley Long; Sarah E Linson; Matthew Ojeda Saavedra; Concepcion Cantu; James J Davis; Thomas Brettin; Randall J Olsen
Journal:  mSphere       Date:  2017-08-02       Impact factor: 4.389

9.  The Rapid Emergence of Tigecycline Resistance in blaKPC-2 Harboring Klebsiella pneumoniae, as Mediated in Vivo by Mutation in tetA During Tigecycline Treatment.

Authors:  Xiaoxing Du; Fang He; Qiucheng Shi; Feng Zhao; Juan Xu; Ying Fu; Yunsong Yu
Journal:  Front Microbiol       Date:  2018-04-05       Impact factor: 5.640

10.  Clinical characteristics in blood stream infections caused by Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae: a comparative study, Japan, 2014-2017.

Authors:  Kazuo Imai; Noriomi Ishibashi; Masahiro Kodana; Norihito Tarumoto; Jun Sakai; Toru Kawamura; Shinichi Takeuchi; Yoshitada Taji; Yasuhiro Ebihara; Kenji Ikebuchi; Takashi Murakami; Takuya Maeda; Kotaro Mitsutake; Shigefumi Maesaki
Journal:  BMC Infect Dis       Date:  2019-11-08       Impact factor: 3.090
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  3 in total

1.  Identification of Plasmid-Mediated Tigecycline-Resistant Gene tet(X4) in Enterobacter cloacae from Pigs in China.

Authors:  Yiping Wu; Ruowen He; Mingyang Qin; Yanxian Yang; Jieyun Chen; Yu Feng; Xiaoxue Liang; Wenbin Deng; Xin Ding; Li-Na Qin; Kang Liao; Yongqiang Yang; Guo-Bao Tian
Journal:  Microbiol Spectr       Date:  2022-03-01

Review 2.  Mobile Tigecycline Resistance: An Emerging Health Catastrophe Requiring Urgent One Health Global Intervention.

Authors:  Madubuike Umunna Anyanwu; Obichukwu Chisom Nwobi; Charles Odilichukwu R Okpala; Ifeoma M Ezeonu
Journal:  Front Microbiol       Date:  2022-08-01       Impact factor: 6.064

3.  A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying blaNDM-4, tet(X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline.

Authors:  Aki Hirabayashi; Trung Duc Dao; Taichiro Takemura; Futoshi Hasebe; Le Thi Trang; Nguyen Ha Thanh; Hoang Huy Tran; Keigo Shibayama; Ikuro Kasuga; Masato Suzuki
Journal:  mSphere       Date:  2021-08-04       Impact factor: 4.389
  3 in total

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