| Literature DB >> 33199233 |
Khaled Alharshawi1, Holger Fey1, Alyx Vogle1, Tori Klenk1, Miran Kim1, Costica Aloman2.
Abstract
Alcoholic liver disease includes a spectrum of clinical and histological entities. They result from the combined direct effect of alcohol and its metabolites on immune cells and resident tissue cells. In humans and mice, females are more susceptible to alcoholic liver injury than males. Despite being involved in sex specific differences of immune mediated tissue injury, plasmacytoid dendritic cells (pDCs) have not been thoroughly assessed as a cellular target of alcohol in humans or mice. Therefore, Meadows-Cook diet was used to study alcohol effect on hepatic dendritic cells. Alcohol consumption for 12 weeks increased hepatic pDCs in female mice. The expression of the C-C chemokine receptor type 2 (CCR2) increased in hepatic pDC of alcohol-fed female mice. Bone marrow transplant chimera showed CCR2 dependent bone marrow egress of pDCs. Chronic alcohol exposure has a sex specific effect on hepatic pDCs population that may explain sex differences to alcoholic liver disease.Entities:
Keywords: Alcohol (EtOH); C-C Chemokine receptor 2 (CCR2); Dendritic cells (DCs); Female (F); Liver injury; Male (M); Meadows-Cook diet (MC); Mouse; Plasmacytoid dendritic cells (pDCs)
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Year: 2020 PMID： 33199233 PMCID： PMC8162836 DOI： 10.1016/j.intimp.2020.107166
Source DB: PubMed Journal: Int Immunopharmacol ISSN： 1567-5769 Impact factor: 4.932