Julius Moratin1, Dominik Horn2, Karl Metzger3, Oliver Ristow3, Christa Flechtenmacher4, Michael Engel3, Jürgen Hoffmann3, Kolja Freier2, Christian Freudlsperger3. 1. University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. J. Hoffmann), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany. Electronic address: Julius.moratin@med.uni-heidelberg.de. 2. Saarland University Hospital, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. K. Freier), Kirrberger Straße, D-66424 Homburg, Germany. 3. University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. J. Hoffmann), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany. 4. University of Heidelberg, Institute of Pathology (Head of Department: Prof. Dr. P. Schirmacher), Im Neuenheimer Feld 224, D-69120 Heidelberg, Germany.
Abstract
INTRODUCTION: Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning. MATERIALS AND METHODS: A retrospective cohort study was designed including patients with squamous cell carcinoma of the mandibular gingiva. Clinical and pathological data were collected to determine the rate of cervical metastases and clinical outcomes depending on tumor stage, localization (anterior, intermediate and posterior) and the extent of tumor resection. RESULTS: 120 patients were included in the analysis. Rate of metastases was 42.6%. Tumors of the anterior part of the mandible exhibited significantly higher rates of bilateral metastases (anterior: 85.7%, intermediate: 15.8%, posterior: 4%, p < 0.001) and local recurrence (anterior: 25%, intermediate: 16.3%, posterior: 5.5%, p = 0.03) compared to posterior malignancies. CONCLUSION: Tumors of the anterior segment of the mandible are characterized by high rates of metastases and local recurrence. Therefore, we propose radical segmental resection and bilateral neck dissection in those patients.
INTRODUCTION: Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning. MATERIALS AND METHODS: A retrospective cohort study was designed including patients with squamous cell carcinoma of the mandibular gingiva. Clinical and pathological data were collected to determine the rate of cervical metastases and clinical outcomes depending on tumor stage, localization (anterior, intermediate and posterior) and the extent of tumor resection. RESULTS: 120 patients were included in the analysis. Rate of metastases was 42.6%. Tumors of the anterior part of the mandible exhibited significantly higher rates of bilateral metastases (anterior: 85.7%, intermediate: 15.8%, posterior: 4%, p < 0.001) and local recurrence (anterior: 25%, intermediate: 16.3%, posterior: 5.5%, p = 0.03) compared to posterior malignancies. CONCLUSION:Tumors of the anterior segment of the mandible are characterized by high rates of metastases and local recurrence. Therefore, we propose radical segmental resection and bilateral neck dissection in those patients.
Authors: Philipp Thoenissen; Anja Heselich; Stefanie Deeg; Sarah Al-Maawi; Anna Tanneberger; Robert Sader; Shahram Ghanaati Journal: Front Oncol Date: 2022-05-24 Impact factor: 5.738
Authors: Davide Sozzi; Andrea Filippi; Gabriele Canzi; Elena De Ponti; Alberto Bozzetti; Giorgio Novelli Journal: J Clin Med Date: 2022-04-06 Impact factor: 4.241