Feyisola P Olatunji1, Jacob W Herman1, Brittany N Kesic1, Damilola Olabode2, Clifford E Berkman1. 1. Washington State University, Department of Chemistry, PO Box 644630, Pullman, WA 99164-4630, United States. 2. Washington State University, Department of Mathematics and Statistics, PO Box 643113, Pullman, WA 99164-3113, United States.
Abstract
In this work, we developed a novel "click"-ready pH-cleavable phosphoramidate linker for controlled-release of monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at physiological pHs while rapidly releasing its payload at acidic pH. The linker can also be tailored to release payloads of diverse functional groups, broadening its applications.
In this work, we developed a novel "click"-ready pH-cleavable phosphoramidate linker for controlled-release of n>an class="Chemical">monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at physiological pHs while rapidly releasing its payload at acidic pH. The linker can also be tailored to release payloads of diverse functional groups, broadening its applications.
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